| Gene Symbol |
FBP2
|
| Entrez Gene |
8789
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fructose-1,6-bisphosphatase 2
|
| Other Description |
D-fructose-1,6-bisphosphate 1-phosphohydrolase 2|FBPase 2|fructose-1,6-bisphosphatase isozyme 2|hexosediphosphatase|muscle FBPase|muscle fructose-bisphosphatase
|
| Swissprots |
Q6FI53 Q17R39 O00757
|
| Accessions |
CAB53359 CAB53360 CAB53361 CAB53362 CAB53363 CAB53364 CAB53365 CAB53366 CAB58560 CAB58561 EAW92616 O00757 AJ573829 BC113632 AAI13633 BC117477 AAI17478 BM686555 BU727940 CR536483 CAG38722 HQ258389 ADR83143 Y10812 CAA71772 XM_011519164 XP_011517466 NM_003837 NP_003828
|
| Function |
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269|PubMed:17350621, ECO:0000269|PubMed:18214967}.
|
| Subcellular Location |
Cell junction {ECO:0000250}. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in skeletal muscle (at protein level). {ECO:0000269|PubMed:12507293}.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Insulin signaling pathway, AMPK signaling pathway, Carbon metabolism
|
![Western Blot: FBP2 Overexpression Lysate (Adult Normal) [NBP2-07944] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FBP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8582_FBP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07944-img0001.jpg)