| Gene Symbol | FBP2 |
|---|---|
| Entrez Gene | 8789 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | fructose-1,6-bisphosphatase 2 |
| Other Description | D-fructose-1,6-bisphosphate 1-phosphohydrolase 2|FBPase 2|fructose-1,6-bisphosphatase isozyme 2|hexosediphosphatase|muscle FBPase|muscle fructose-bisphosphatase |
| Swissprots | Q6FI53 Q17R39 O00757 |
| Accessions | CAB53359 CAB53360 CAB53361 CAB53362 CAB53363 CAB53364 CAB53365 CAB53366 CAB58560 CAB58561 EAW92616 O00757 AJ573829 BC113632 AAI13633 BC117477 AAI17478 BM686555 BU727940 CR536483 CAG38722 HQ258389 ADR83143 Y10812 CAA71772 XM_011519164 XP_011517466 NM_003837 NP_003828 |
| Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269|PubMed:17350621, ECO:0000269|PubMed:18214967}. |
| Subcellular Location | Cell junction {ECO:0000250}. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}. |
| Tissue Specificity | Expressed in skeletal muscle (at protein level). {ECO:0000269|PubMed:12507293}. |
| Top Pathways | Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Insulin signaling pathway, AMPK signaling pathway, Carbon metabolism |
muscle FBPase CRISPR/Cas9 KO Plasmid (h) - sc-411210 from Santa Cruz Biotechnology
|
||||||||
muscle FBPase HDR Plasmid (h) - sc-411210-HDR from Santa Cruz Biotechnology
|
||||||||
muscle FBPase Double Nickase Plasmid (h) - sc-411210-NIC from Santa Cruz Biotechnology
|
||||||||
muscle FBPase Double Nickase Plasmid (h2) - sc-411210-NIC-2 from Santa Cruz Biotechnology
|
||||||||
muscle FBPase CRISPR Activation Plasmid (h) - sc-411210-ACT from Santa Cruz Biotechnology
|
||||||||
muscle FBPase CRISPR Activation Plasmid (h2) - sc-411210-ACT-2 from Santa Cruz Biotechnology
|
||||||||
muscle FBPase Lentiviral Activation Particles (h) - sc-411210-LAC from Santa Cruz Biotechnology
|
||||||||
muscle FBPase Lentiviral Activation Particles (h2) - sc-411210-LAC-2 from Santa Cruz Biotechnology
|
||||||||
muscle FBPase siRNA (h) - sc-45239 from Santa Cruz Biotechnology
|
||||||||
muscle FBPase shRNA Plasmid (h) - sc-45239-SH from Santa Cruz Biotechnology
|
||||||||
muscle FBPase shRNA (h) Lentiviral Particles - sc-45239-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU024661 from Sigma-Aldrich
|
||||||||
MISSION® Human Phosphatase - SIHP0224 from Sigma-Aldrich
|
||||||||
MISSION® Human Phosphatase - SIHP0223 from Sigma-Aldrich
|
||||||||
MISSION® Human Phosphatase - SIHP0225 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN8511 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8511 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR11982 from Sigma-Aldrich
|
||||||||
FBP2 siRNA (Human) - CRH5790 from Cohesion Biosciences
|
||||||||
FBP2 - MBS8231383 from MyBioSource
|
||||||||
shRNA set against Human FBP2 (NM_003837.2) - SHH292777 from Creative biogene
|
||||||||
shRNA set against Human FBP2(NM_003837.2) - SHH050631 from Creative biogene
|
||||||||
Human FBP2 siRNA - orb266292 from Biorbyt
|
||||||||
FBP2 shRNA Plasmid (Human) - CHH5790 from Cohesion Biosciences
|
||||||||
FBP2 miRNA 3'UTR clone - MiUTR1H-03537 from Creative biogene
|