HRH4

Gene Symbol HRH4
Entrez Gene 59340
Alt Symbol AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R
Species Human
Gene Type protein-coding
Description histamine receptor H4
Other Description G-protein coupled receptor 105|SP9144|histamine H4 receptor|pfi-013
Swissprots B2KJ48 Q9GZQ0 Q4G0I6 B0YJ19 Q9H3N8
Accessions ACA05997 EAX01189 Q9H3N8 AB044934 BAB13698 AB045370 BAB20091 AF307973 AAG32052 AF312230 AAK12081 AF325356 AAL01684 AF329449 AAK43542 AJ298292 CAC83493 AY008280 AAL09297 AY136745 AAN01271 BC069136 AAH69136 BC112348 AAI12349 DQ835186 ABI54174 DQ835187 ABI54175 XM_011526133 XP_011524435 XM_011526134 XP_011524436 NM_001143828 NP_001137300 NM_001160166 NP_001153638 NM_021624 NP_067637
Function The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). {ECO:0000269|PubMed:12503632}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. {ECO:0000269|PubMed:12503632}.
Top Pathways Neuroactive ligand-receptor interaction

Histamine H4 Receptor (H-110) - sc-50312 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Histamine H4 Receptor (H-110) : sc-50312. Western blot analysis of Histamine H4 Receptor in human plasma (A) and Histamine H4 Receptor expression in AN3 CA (B), Raji (C) and HEL 92.1.7 (D) whole cell lysates.

Histamine H4 Receptor (C-20) - sc-19777 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Histamine H4 Receptor (L-15) - sc-33966 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Histamine H4 Receptor (Q-20) - sc-33965 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Histamine H4 Receptor (Y-19) - sc-33967 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HRH4 antibody - ab97487 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab97487 stained HCT116 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab97487 at 10 µg/mL overnight at +4°C. The secondary antibody (green) was DyLight® 488 Goat anti-Rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-HRH4 antibody - ab188978 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human lymph node tissue labeling HRH4 with ab188978 at 24 µg/ml.

Anti-HRH4 antibody - ab129860 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HRH4 antibody (ab129860) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-HRH4 antibody - ab125393 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HRH4 antibody (ab125393) at 1 µg/ml + 721_B cell lysate at 10 µg

Anti-HRH4 antibody - C-terminal - ab189042 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver sections labeling HRH4 with ab189042 at 10 µg/ml.

Anti-HRH4 antibody - Cytoplasmic domain - ab189054 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lymph node labeling HRH4 with ab189054 at 14µg/ml

Anti-HRH4 / Histamine H4 Receptor Antibody (C-Terminus) - LS-C24244 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HRH4 / Histamine H4 Receptor Antibody (aa227-256, Biotin) - LS-C215169 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH4 / Histamine H4 Receptor Antibody (aa227-256, AP) - LS-C215168 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH4 / Histamine H4 Receptor Antibody (aa227-256, APC) - LS-C215170 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH4 / Histamine H4 Receptor Antibody (aa227-256, FITC) - LS-C215171 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH4 / Histamine H4 Receptor Antibody (aa227-256, Azide-free, HRP) - LS-C215172 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH4 / Histamine H4 Receptor Antibody (aa227-256, PE) - LS-C215175 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH4 / Histamine H4 Receptor Antibody (aa227-256) - LS-C322097 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH4 / Histamine H4 Receptor Antibody (aa221-270) - LS-C199078 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using HRH4 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-HRH4 / Histamine H4 Receptor Antibody (aa142-191) - LS-C146254 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HRH4 / Histamine H4 Receptor antibody LS-C146254 Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.

Anti-HRH4 / Histamine H4 Receptor Antibody (aa228-256) - LS-C165018 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HRH4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The HRH4 antibody detected the HRH4 protein (arrow).

Anti-HRH4 / Histamine H4 Receptor Antibody (aa1-82) - LS-C185370 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: A431 . 10% SDS PAGE. Histamine H4 Receptor antibody diluted at 1:1000.

Anti-HRH4 / Histamine H4 Receptor Antibody (Extracellular Domain) IHC-plus™ - LS-A1901 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HRH4 / Histamine H4 Receptor antibody LS-A1901 IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HRH4 / Histamine H4 Receptor Antibody (C-Terminus) IHC-plus™ - LS-A3785 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human, Liver: Formalin-Fixed Paraffin-Embedded (FFPE)
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