Gene Symbol | HRH4 |
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Entrez Gene | 59340 |
Alt Symbol | AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R |
Species | Human |
Gene Type | protein-coding |
Description | histamine receptor H4 |
Other Description | G-protein coupled receptor 105|SP9144|histamine H4 receptor|pfi-013 |
Swissprots | B2KJ48 Q9GZQ0 Q4G0I6 B0YJ19 Q9H3N8 |
Accessions | ACA05997 EAX01189 Q9H3N8 AB044934 BAB13698 AB045370 BAB20091 AF307973 AAG32052 AF312230 AAK12081 AF325356 AAL01684 AF329449 AAK43542 AJ298292 CAC83493 AY008280 AAL09297 AY136745 AAN01271 BC069136 AAH69136 BC112348 AAI12349 DQ835186 ABI54174 DQ835187 ABI54175 XM_011526133 XP_011524435 XM_011526134 XP_011524436 NM_001143828 NP_001137300 NM_001160166 NP_001153638 NM_021624 NP_067637 |
Function | The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). {ECO:0000269|PubMed:12503632}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. {ECO:0000269|PubMed:12503632}. |
Top Pathways | Neuroactive ligand-receptor interaction |
HRH4 peptide - ab109635 from Abcam
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Human HRH4 protein fragment - ab153469 from Abcam
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HRH4 / Histamine H4 Receptor Antibody Blocking Peptide - LS-E4671 from LifeSpan Bioscience
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HRH4 / Histamine H4 Receptor Antibody Blocking Peptide - LS-E28813 from LifeSpan Bioscience
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HRH4 / Histamine H4 Receptor Antibody Blocking Peptide - LS-E28811 from LifeSpan Bioscience
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HRH4 / Histamine H4 Receptor Antibody Blocking Peptide - LS-E28428 from LifeSpan Bioscience
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HRH4 / Histamine H4 Receptor Antibody Blocking Peptide - LS-E23186 from LifeSpan Bioscience
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HRH4 / Histamine H4 Receptor Antibody Blocking Peptide - LS-E29195 from LifeSpan Bioscience
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Recombinant Human Histamine H4 R Protein - H00059340-Q01 from Novus Biologicals
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HRH4-Antibody-Center-Blocking-Peptide - BP17035c from Abgent, a WuXi AppTec company
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Histamine H4 receptor - H00059340-Q01-10 from Acris Antibodies
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Histamine H4 receptor - H00059340-Q01-25 from Acris Antibodies
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Recombinant Histamine Receptor H4 (HRH4) - RPG040Hu01 from Uscn Life Science Inc.
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Recombinant Histamine Receptor H4 (HRH4) - RPG040Mu01 from Uscn Life Science Inc.
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Recombinant Histamine Receptor H4 (HRH4) - RPG040Mu02 from Uscn Life Science Inc.
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Recombinant Histamine Receptor H4 (HRH4) - RPG040Ra01 from Uscn Life Science Inc.
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Recombinant Histamine Receptor H4 (HRH4) - RPG040Hu01 from Cloud-clone
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Histamine H4 receptor - H00059340-Q01 from Acris Antibodies
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Histamine H4 R Recombinant Protein Antigen - NBP1-90058PEP from Novus Biologicals
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HRH4-Antibody-C-term-Blocking-Peptide - BP1701b from Abgent, a WuXi AppTec company
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HRH4 Peptide, Human - M34GP07252H from Creative Peptides
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Histamine H4 receptor (HRH4), Recombinant Protein - MBS7016752 from MyBioSource
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