| Gene Symbol |
HRH4
|
| Entrez Gene |
59340
|
| Alt Symbol |
AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histamine receptor H4
|
| Other Description |
G-protein coupled receptor 105|SP9144|histamine H4 receptor|pfi-013
|
| Swissprots |
B2KJ48 Q9GZQ0 Q4G0I6 B0YJ19 Q9H3N8
|
| Accessions |
ACA05997 EAX01189 Q9H3N8 AB044934 BAB13698 AB045370 BAB20091 AF307973 AAG32052 AF312230 AAK12081 AF325356 AAL01684 AF329449 AAK43542 AJ298292 CAC83493 AY008280 AAL09297 AY136745 AAN01271 BC069136 AAH69136 BC112348 AAI12349 DQ835186 ABI54174 DQ835187 ABI54175 XM_011526133 XP_011524435 XM_011526134 XP_011524436 NM_001143828 NP_001137300 NM_001160166 NP_001153638 NM_021624 NP_067637
|
| Function |
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). {ECO:0000269|PubMed:12503632}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. {ECO:0000269|PubMed:12503632}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|