YES1

Gene Symbol	YES1
Entrez Gene	7525
Alt Symbol	HsT441, P61-YES, Yes, c-yes
Species	Human
Gene Type	protein-coding
Description	YES proto-oncogene 1, Src family tyrosine kinase
Other Description	YES1 proto-oncogene, Src family tyrosine kinase|Yamaguchi sarcoma oncogene|cellular yes-1 protein|proto-oncogene c-Yes|proto-oncogene tyrosine-protein kinase YES|tyrosine-protein kinase Yes|v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Swissprots	P07947 D3DUH1 A6NLB3
Accessions	CCQ43321 EAX01709 EAX01710 P07947 AK314063 BAG36767 AU123956 BC031080 BC048960 AAH48960 BM969640 BU753688 H80401 M15990 AAA35735 XM_005258139 XP_005258196 XM_011525736 XP_011524038 NM_005433 NP_005424
Function	Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in
Subcellular Location	Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
Tissue Specificity	Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. {ECO:0000269|PubMed:2021534, ECO:0000269|PubMed:2067846}.
Top Pathways	Adherens junction, Tight junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Phospho-Yes (Y426) DuoSet IC ELISA, 2 Plate - DYC3929-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 31.20 - 2,000 pg/mL

Tyrosine-protein kinase Yes (YES1), Human, ELISA Kit - CSB-EL026253HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Tyrosine-protein kinase Yes (YES1), Human, ELISA Kit - E01T0748 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

YES1 (Human) IP-WB Antibody Pair - H00007525-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Tyrosine protein kinase Yes (YES1), ELISA Kit - MBS7218835 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7202832 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7246381 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7220029 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7249213 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7236438 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7234665 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7216746 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7201168 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7253146 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Yes (YES1), ELISA Kit - MBS7251174 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1, ELISA Kit - MBS918789 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human YES1 is typically less than 6.25 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml -1600 pg/ml.

Human Tyrosine-protein kinase Yes(YES1) ELISA kit - CSB-EL026253HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human YES1 ELISA Kit - E103073 from Biobool Category ELISA Kit

Human Phospho-Yes (Y426) DuoSet IC - DYC3929-5 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit

YES1 ELISA Kit (Human) (OKCA01579) - OKCA01579 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 6.25 pg/mL Range 25 - 1,600 pg/mL

Tyrosine-protein kinase Yes, ELISA Kit - MBS284726 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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