| Gene Symbol | YES1 |
|---|---|
| Entrez Gene | 7525 |
| Alt Symbol | HsT441, P61-YES, Yes, c-yes |
| Species | Human |
| Gene Type | protein-coding |
| Description | YES proto-oncogene 1, Src family tyrosine kinase |
| Other Description | YES1 proto-oncogene, Src family tyrosine kinase|Yamaguchi sarcoma oncogene|cellular yes-1 protein|proto-oncogene c-Yes|proto-oncogene tyrosine-protein kinase YES|tyrosine-protein kinase Yes|v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
| Swissprots | P07947 D3DUH1 A6NLB3 |
| Accessions | CCQ43321 EAX01709 EAX01710 P07947 AK314063 BAG36767 AU123956 BC031080 BC048960 AAH48960 BM969640 BU753688 H80401 M15990 AAA35735 XM_005258139 XP_005258196 XM_011525736 XP_011524038 NM_005433 NP_005424 |
| Function | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in |
| Subcellular Location | Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. |
| Tissue Specificity | Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. {ECO:0000269|PubMed:2021534, ECO:0000269|PubMed:2067846}. |
| Top Pathways | Adherens junction, Tight junction |