YES1

Gene Symbol	YES1
Entrez Gene	7525
Alt Symbol	HsT441, P61-YES, Yes, c-yes
Species	Human
Gene Type	protein-coding
Description	YES proto-oncogene 1, Src family tyrosine kinase
Other Description	YES1 proto-oncogene, Src family tyrosine kinase|Yamaguchi sarcoma oncogene|cellular yes-1 protein|proto-oncogene c-Yes|proto-oncogene tyrosine-protein kinase YES|tyrosine-protein kinase Yes|v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Swissprots	P07947 D3DUH1 A6NLB3
Accessions	CCQ43321 EAX01709 EAX01710 P07947 AK314063 BAG36767 AU123956 BC031080 BC048960 AAH48960 BM969640 BU753688 H80401 M15990 AAA35735 XM_005258139 XP_005258196 XM_011525736 XP_011524038 NM_005433 NP_005424
Function	Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in
Subcellular Location	Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
Tissue Specificity	Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. {ECO:0000269|PubMed:2021534, ECO:0000269|PubMed:2067846}.
Top Pathways	Adherens junction, Tight junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

c-Yes CRISPR/Cas9 KO Plasmid (h) - sc-400261 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Yes HDR Plasmid (h) - sc-400261-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Yes Double Nickase Plasmid (h) - sc-400261-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Yes Double Nickase Plasmid (h2) - sc-400261-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Yes CRISPR Activation Plasmid (h) - sc-400261-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Yes CRISPR Activation Plasmid (h2) - sc-400261-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Yes Lentiviral Activation Particles (h) - sc-400261-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Yes Lentiviral Activation Particles (h2) - sc-400261-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Yes siRNA (h) - sc-29860 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Yes shRNA Plasmid (h) - sc-29860-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Yes shRNA (h) Lentiviral Particles - sc-29860-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Yes RNAi - H00007525-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Yes RNAi - H00007525-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU103601 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK2479 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2481 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2480 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2292 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2292 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

YES1 siRNA (Human) - CRH5141 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

YES1 - MBS8228209 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human YES1 (NM_005433.3) - SHH448344 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human YES1(NM_005433.3) - SHL139798 from Creative biogene Category siRNA Species Reactivities Human

Human YES1 siRNA - orb265643 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

YES1 shRNA Plasmid (Human) - CHH5141 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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