YES1

Gene Symbol	YES1
Entrez Gene	7525
Alt Symbol	HsT441, P61-YES, Yes, c-yes
Species	Human
Gene Type	protein-coding
Description	YES proto-oncogene 1, Src family tyrosine kinase
Other Description	YES1 proto-oncogene, Src family tyrosine kinase|Yamaguchi sarcoma oncogene|cellular yes-1 protein|proto-oncogene c-Yes|proto-oncogene tyrosine-protein kinase YES|tyrosine-protein kinase Yes|v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Swissprots	P07947 D3DUH1 A6NLB3
Accessions	CCQ43321 EAX01709 EAX01710 P07947 AK314063 BAG36767 AU123956 BC031080 BC048960 AAH48960 BM969640 BU753688 H80401 M15990 AAA35735 XM_005258139 XP_005258196 XM_011525736 XP_011524038 NM_005433 NP_005424
Function	Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in
Subcellular Location	Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
Tissue Specificity	Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. {ECO:0000269|PubMed:2021534, ECO:0000269|PubMed:2067846}.
Top Pathways	Adherens junction, Tight junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Yes1 full length protein - ab101504 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus Species Human

YES1 / c-Yes Antibody Blocking Peptide - LS-E3309 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

YES1 / c-Yes Antibody Blocking Peptide - LS-E7320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

YES1 / c-Yes Antibody Blocking Peptide - LS-E9225 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Yes Protein - H00007525-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Yes Protein - H00007525-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Yes Recombinant Protein - P4797 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Yes Peptide - P2770 from Novus Biologicals Category Peptide Species Human

Yes Peptide - P1420 from Novus Biologicals Category Peptide Species Human

YES1-Antibody-N-term-Blocking-peptide - BP7725a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human c Yes protein - orb84150 from Biorbyt Category Protein Prices $323.00, $400.00 Sizes 20 μg, 10 μg Source Insect Species Human

YES1 - H00007525-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

YES1 - H00007525-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

YES1 - H00007525-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

YES1 - H00007525-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

YES1 - P4797 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

YES1 - P5753 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

YES1 - P5811 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

YES1 fusion protein - Ag5016 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

YES1 fusion protein - ag4827 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RR-SRC Peptide - 350370 from ABBIOTEC Category Peptide Prices $130.00 Sizes 5 mg

Recombinant Yes protein - 31202 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source Baculovirus Species Human

Recombinant Human YES1, UD Domain - YES1-237H from Creative Biomart Category Protein Source Recombinant Human full length YES1 UD domain protein expressed in E.coli .

Recombinant Human YES1, GST-His - YES1-708H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human YES1, His & GST tagged - YES1-3930H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

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