YES1

Gene Symbol YES1
Entrez Gene 7525
Alt Symbol HsT441, P61-YES, Yes, c-yes
Species Human
Gene Type protein-coding
Description YES proto-oncogene 1, Src family tyrosine kinase
Other Description YES1 proto-oncogene, Src family tyrosine kinase|Yamaguchi sarcoma oncogene|cellular yes-1 protein|proto-oncogene c-Yes|proto-oncogene tyrosine-protein kinase YES|tyrosine-protein kinase Yes|v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Swissprots P07947 D3DUH1 A6NLB3
Accessions CCQ43321 EAX01709 EAX01710 P07947 AK314063 BAG36767 AU123956 BC031080 BC048960 AAH48960 BM969640 BU753688 H80401 M15990 AAA35735 XM_005258139 XP_005258196 XM_011525736 XP_011524038 NM_005433 NP_005424
Function Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in
Subcellular Location Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
Tissue Specificity Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. {ECO:0000269|PubMed:2021534, ECO:0000269|PubMed:2067846}.
Top Pathways Adherens junction, Tight junction

Yes Antibody - 3201 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Yes Antibody.

Yes Antibody - 2734 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from SEM and U-87 MG cells using Yes Antibody.

c-Yes (C-10) - sc-46674 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Yes (C-10): sc-46674. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

c-Yes (3) - sc-14 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-Yes (3): sc-14. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic and membrane staining of glandular cells.

c-Yes (2F3E6) - sc-130055 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Yes (2F3E6): sc-130055. Western blot analysis of c-Yes expression in Jurkat (A), C32 (B), T98G (C), A-431 (D) and JAR (E) whole cell lysates.

c-Yes (C-4) - sc-48396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Yes (C-4): sc-48396. Western blot analysis of c-Yes expression in Jurkat whole cell lysate.

c-Yes (F-7) - sc-8403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Yes (F-7): sc-8403. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing localized staining within the cell.

c-Yes (H-95) - sc-28883 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-Yes (H-95): sc-28883. Western blot analysis of c-Yes expression in human platelet extract.

c-Yes (T-20) - sc-30676 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
c-Yes (T-20): sc-30676. Western blot analysis of c-Yes expression in Jurkat whole cell lysate.

p-c-Yes (Tyr 537) - sc-130182 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-c-Yes (Tyr 527): sc-130182. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.

Anti-Yes1 (phospho Y537) antibody - ab60028 from Abcam

Prices $313.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin fixed and paraffin embedded human hepatocarcinoma tissue reacted with ab60028 at a dilution of 1/50, which was peroxidase conjugated to the secondary antibody, followed by AEC staining.

Anti-Yes1 antibody - ab61206 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-Yes1 antibody (ab61206) at 1 µg/ml + A431 whole cell lysate at 50 µg/mlSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-Yes1 antibody - ab13954 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Yes1 antibody [EPR3172] - ab133314 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3172
All lanes : Anti-Yes1 antibody [EPR3172] (ab133314) at 1/1000 dilutionLane 1 : U87-MG cell lysateLane 2 : Molt-4 cell lysateLane 3 : LnCaP cell lysate Lane 4 : A431 cell lysate Lysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Yes1 antibody [EPR3173] - ab109265 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3173
All lanes : Anti-Yes1 antibody [EPR3173] (ab109265) at 1/1000 dilutionLane 1 : U-87 MG cell lysateLane 2 : SW480 cell lysate Lane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-YES1 / c-Yes Antibody (aa1-252) - LS-C40275 from LifeSpan Bioscience

Prices $485.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-YES1 / c-Yes Antibody (N-Terminus) - LS-C40277 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-YES1 / c-Yes Antibody - LS-C40276 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-YES1 / c-Yes Antibody - LS-C132967 from LifeSpan Bioscience

Prices $845.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-YES1 / c-Yes Antibody (aa1-30, AP) - LS-C273790 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-YES1 / c-Yes Antibody (aa1-30, APC) - LS-C273791 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-YES1 / c-Yes Antibody (clone 2F3E6) - LS-C108741 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F3E6
Western blot using YES1 mouse monoclonal antibody against truncated YES1-His recombinant protein (1) and full-length GFP-YES1(aa1-543) transfected COS7 cell lysate (2).

Anti-YES1 / c-Yes Antibody (aa1-30, Biotin) - LS-C273792 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-YES1 / c-Yes Antibody (aa1-30, Azide-free, HRP) - LS-C273793 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-YES1 / c-Yes Antibody (aa1-30, FITC) - LS-C273794 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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