PDE10A

Gene Symbol PDE10A
Entrez Gene 10846
Alt Symbol HSPDE10A
Species Human
Gene Type protein-coding
Description phosphodiesterase 10A
Other Description cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A|dJ416F21.1 (phosphodiesterase 10A)|phosphodiesterase 10A1 (PDE10A1)
Swissprots Q9Y5T1 Q9HCP9 Q9Y233 Q9NTV4 Q6FHX1 Q9ULW9
Accessions BAB16383 BAB92963 CAJ29925 EAW47546 Q9Y233 AB020593 BAA78034 AB026816 BAA84467 AF127479 AAD32595 AF127480 AAD32596 AI632009 AK021956 AK098543 AK297555 BAG59948 BC104858 AAI04859 BC104860 AAI04861 BC143297 BC143301 CR536567 CAG38804 DR000181 XM_006715321 XP_006715384 XM_011535387 XP_011533689 XM_011535388 XP_011533690 XM_011535389 XP_011533691 XM_011535390 XP_011533692 XM_011535391 XP_011533693 XM_011535392 XP_011533694 XM_011535393 XP_011533695 NM_001130690 NP_001124162 NM_006661 NP_006652 NR_045597
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. {ECO:0000269|PubMed:17389385}.
Subcellular Location Cytoplasm. Note=Located mostly to soluble cellular fractions.
Tissue Specificity Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Top Pathways Morphine addiction, Purine metabolism

PDE10A (C-17) - sc-66502 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PDE10A (E-20) - sc-66503 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PDE10A (H-219) - sc-67298 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PDE10A (Y-19) - sc-66505 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE10A (Y-19): sc-66505. Western blot analysis of PDE10A expression in HeLa whole cell lysate.

Anti-PDE10A antibody - ab14622 from Abcam

Prices $372.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE10A antibody - ab125671 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDE10A antibody (ab125671) at 1/2000 dilutionLane 1 : COS cells, non- transfectedLane 2 : COS cells, transfected with Human PDE1A3Lane 3 : COS cells, transfected with Human PDE2A3Lane 4 : COS cells, transfected with Human PDE3ALane 5 : COS cells, transfected with Human PDE3BLane 6 : COS cells, transfected with Human PDE4D2Lane 7 : COS cells, transfected with Human PDE5A1Lane 8 : COS cells, transfected with Human PDE5A3Lane 9 : COS cells, transfected with Human PDE7A1Lane 10 : COS cells, transfected with Human PDE8A1Lane 11 : COS cells, transfected with Human PDE10A1Lane 12 : COS cells, transfected with Human PDE11A1developed using the ECL technique

Anti-PDE10A antibody [3G9] - ab114025 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G9
Immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PDE10A, using ab114025 1/100

Anti-PDE10A antibody [4A10] - ab117950 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4A10
All lanes : Anti-PDE10A antibody [4A10] (ab117950) at 1/200 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY PDE10A cDNALysates/proteins at 5 µg per lane.

Anti-PDE10A antibody [EPR12835] - ab177933 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12835
All lanes : Anti-PDE10A antibody [EPR12835] (ab177933) at 1/1000 dilutionLane 1 : Fetal brain lysateLane 2 : Fetal kidney lysateLane 3 : 293T lysateLane 4 : HeLa lysateLysates/proteins at 10 µg per lane.

Anti-PDE10A antibody - C-terminal - ab151454 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human Cal27 xenograft tissue labeling PDE10A with ab151454 at 1/500.

Anti-PDE10A antibody - N-terminal - ab186913 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PDE10A antibody - N-terminal (ab186913) at 1 µg/ml + PANC1 whole cell lysates at 10 µg

Anti-PDE10A Antibody (N-Terminus) - LS-C90201 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE10A Antibody (aa21-70) - LS-C291295 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE10A Antibody - LS-C181066 from LifeSpan Bioscience

Prices $335.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE10A Antibody (C-Terminus) - LS-C82354 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Image of Western blot of PDE10A antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.

Anti-PDE10A Antibody (aa24-73) - LS-C206155 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PDE10A antibody Western Blot of PANC1. Antibody dilution: 1 ug/ml.

Anti-PDE10A Antibody (clone 4A10) - LS-C172334 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4A10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE10A (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDE10A.

Anti-PDE10A Antibody (clone 1C9) - LS-C114721 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C9
IHC of paraffin-embedded endometrium tissue using anti-PDE10A mouse monoclonal antibody. (Dilution 1:50).

PDE10A Antibody - NB300-645 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PDE10A Antibody [NB300-645] - NB300-645 (1:500) using CNS Blot. 1. Frontal Cortex 2. Pariental Cortex 3. Striatum 4. Amygdela 5. Hypothalamus 6. Hippocampus 7. Olfactory bulb 8. Brain Stem 9. Cerebellum 10. Spinal cord and 11. Whole Brain.

PDE10A Antibody (1C9) - NBP1-47909 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C9

PDE10A Antibody - NBP2-19742 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PDE10A Antibody [NBP2-19742] - Sample (30 ug of whole cell lysate) A: Hela 7. 5% SDS PAGE gel, diluted at 1:3000.

PDE10A Antibody - NBP1-00630 from Novus Biologicals

Prices $459.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PDE10A Antibody [NBP1-00630] - Image of western blot using PDE10A antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform

PDE10A Antibody - NB110-74586 from Novus Biologicals

Host Rabbit
Clonality Polyclonal

Anti-PDE10A (41-55) antibody produced in rabbit - SAB1105191 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE10A (706-720) antibody produced in rabbit - SAB1105192 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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