| Gene Symbol |
PDE10A
|
| Entrez Gene |
10846
|
| Alt Symbol |
HSPDE10A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 10A
|
| Other Description |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A|dJ416F21.1 (phosphodiesterase 10A)|phosphodiesterase 10A1 (PDE10A1)
|
| Swissprots |
Q9Y5T1 Q9HCP9 Q9Y233 Q9NTV4 Q6FHX1 Q9ULW9
|
| Accessions |
BAB16383 BAB92963 CAJ29925 EAW47546 Q9Y233 AB020593 BAA78034 AB026816 BAA84467 AF127479 AAD32595 AF127480 AAD32596 AI632009 AK021956 AK098543 AK297555 BAG59948 BC104858 AAI04859 BC104860 AAI04861 BC143297 BC143301 CR536567 CAG38804 DR000181 XM_006715321 XP_006715384 XM_011535387 XP_011533689 XM_011535388 XP_011533690 XM_011535389 XP_011533691 XM_011535390 XP_011533692 XM_011535391 XP_011533693 XM_011535392 XP_011533694 XM_011535393 XP_011533695 NM_001130690 NP_001124162 NM_006661 NP_006652 NR_045597
|
| Function |
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. {ECO:0000269|PubMed:17389385}.
|
| Subcellular Location |
Cytoplasm. Note=Located mostly to soluble cellular fractions.
|
| Tissue Specificity |
Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
|
| Top Pathways |
Morphine addiction, Purine metabolism
|