SMPD3

Gene Symbol	SMPD3
Entrez Gene	55512
Alt Symbol	NSMASE2
Species	Human
Gene Type	protein-coding
Description	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Other Description	nSMase-2|neutral sphingomyelinase 2|neutral sphingomyelinase II|sphingomyelin phosphodiesterase 3
Swissprots	B7ZL82 Q9NY59 Q2M1S8
Accessions	ACV30039 ADG64729 ADG64730 CAD35076 CCF76927 EAW83233 Q9NY59 AA461272 AJ250460 CAB92964 AK026246 BAB15409 AK289651 BAF82340 AL157660 AW163364 BC012727 BC041828 BC112238 AAI12239 BC143631 AAI43632 BC143634 AAI43635 BI196095 CA424980 CB268111 DQ424899 ABD83664 HQ258353 ADR83107 XM_005256031 XP_005256088 XM_005256032 XP_005256089 XM_011523207 XP_011521509 XM_011523208 XP_011521510 XM_011523209 XP_011521511 XM_011523210 XP_011521512 XR_933371 NM_018667 NP_061137
Function	Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. {ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}.
Subcellular Location	Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells.
Tissue Specificity	Predominantly expressed in brain. {ECO:0000269|PubMed:10823942}.
Top Pathways	Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMPD3 (Human) IP-WB Antibody Pair - H00055512-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) , ELISA Kit - MBS9337041 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.5ng/ml-16ng/ml.

Human SMPD3 ELISA Kit - E091748 from Biobool Category ELISA Kit

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9371522 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9375947 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9378203 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9376466 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9374087 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9379783 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9371684 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9377937 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9371041 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9378851 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9380685 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9376500 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9370281 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9376701 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SMPD3 (Sphingomyelin phosphodiesterase 3), ELISA Kit - MBS7606092 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9381497 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9381180 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9378285 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9370745 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9370687 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9377078 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sphingomyelin Phosphodiesterase 3 (SMPD3), ELISA Kit - MBS9375012 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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