SMPD3

Gene Symbol SMPD3
Entrez Gene 55512
Alt Symbol NSMASE2
Species Human
Gene Type protein-coding
Description sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Other Description nSMase-2|neutral sphingomyelinase 2|neutral sphingomyelinase II|sphingomyelin phosphodiesterase 3
Swissprots B7ZL82 Q9NY59 Q2M1S8
Accessions ACV30039 ADG64729 ADG64730 CAD35076 CCF76927 EAW83233 Q9NY59 AA461272 AJ250460 CAB92964 AK026246 BAB15409 AK289651 BAF82340 AL157660 AW163364 BC012727 BC041828 BC112238 AAI12239 BC143631 AAI43632 BC143634 AAI43635 BI196095 CA424980 CB268111 DQ424899 ABD83664 HQ258353 ADR83107 XM_005256031 XP_005256088 XM_005256032 XP_005256089 XM_011523207 XP_011521509 XM_011523208 XP_011521510 XM_011523209 XP_011521511 XM_011523210 XP_011521512 XR_933371 NM_018667 NP_061137
Function Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. {ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}.
Subcellular Location Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells.
Tissue Specificity Predominantly expressed in brain. {ECO:0000269|PubMed:10823942}.
Top Pathways Sphingolipid metabolism

N-SMase2 CRISPR/Cas9 KO Plasmid (h) - sc-401937 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

N-SMase2 HDR Plasmid (h) - sc-401937-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

N-SMase2 Double Nickase Plasmid (h) - sc-401937-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

N-SMase2 Double Nickase Plasmid (h2) - sc-401937-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

N-SMase2 CRISPR Activation Plasmid (h) - sc-401937-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

N-SMase2 CRISPR Activation Plasmid (h2) - sc-401937-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

N-SMase2 Lentiviral Activation Particles (h) - sc-401937-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

N-SMase2 Lentiviral Activation Particles (h2) - sc-401937-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

N-SMase2 siRNA (h) - sc-62655 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

N-SMase2 shRNA Plasmid (h) - sc-62655-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

N-SMase2 shRNA (h) Lentiviral Particles - sc-62655-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU024631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2439 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2439 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11886 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11886

SMPD3 siRNA (Human) - CRJ0721 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMPD3 - MBS8201019 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SMPD3 (NM_018667.3) - SHH413580 from Creative biogene

Category siRNA
Species Reactivities Human

Human SMPD3 siRNA - orb271222 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMPD3 shRNA Plasmid (Human) - CHJ0721 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SMPD3 miRNA 3'UTR clone - MiUTR4H-TG08338 from Creative biogene

Species Reactivities Human
Search more