SMPD3

Gene Symbol	SMPD3
Entrez Gene	55512
Alt Symbol	NSMASE2
Species	Human
Gene Type	protein-coding
Description	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Other Description	nSMase-2|neutral sphingomyelinase 2|neutral sphingomyelinase II|sphingomyelin phosphodiesterase 3
Swissprots	B7ZL82 Q9NY59 Q2M1S8
Accessions	ACV30039 ADG64729 ADG64730 CAD35076 CCF76927 EAW83233 Q9NY59 AA461272 AJ250460 CAB92964 AK026246 BAB15409 AK289651 BAF82340 AL157660 AW163364 BC012727 BC041828 BC112238 AAI12239 BC143631 AAI43632 BC143634 AAI43635 BI196095 CA424980 CB268111 DQ424899 ABD83664 HQ258353 ADR83107 XM_005256031 XP_005256088 XM_005256032 XP_005256089 XM_011523207 XP_011521509 XM_011523208 XP_011521510 XM_011523209 XP_011521511 XM_011523210 XP_011521512 XR_933371 NM_018667 NP_061137
Function	Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. {ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}.
Subcellular Location	Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells.
Tissue Specificity	Predominantly expressed in brain. {ECO:0000269|PubMed:10823942}.
Top Pathways	Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NSMase2 full length protein - ab112416 from Abcam Category Protein Source Wheat germ Species Human

Human NSMase2 peptide - ab95417 from Abcam Category Peptide

Human NSMase2 protein fragment - ab153401 from Abcam Category Protein Source Wheat germ Species Human

SMPD3 / NSMASE2 Antibody Blocking Peptide - LS-E6364 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SMPD3/NSMase2 Protein - H00055512-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SMPD3/NSMase2 Protein - H00055512-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SMPD3-Antibody-N-term-Blocking-Peptide - BP19071a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMPD3 Blocking Peptide - 33R-8099 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SMPD3 - H00055512-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SMPD3 - H00055512-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SMPD3 - H00055512-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SMPD3 - H00055512-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SMPD3 Control Peptide - AP05301CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

SMPD3 fusion protein - ag19631 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SMPD3 - SMPD3-29444TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Sphingomyelin phosphodiesterase 3(SMPD3) - CSB-YP878920HU CSB-EP878920HU CSB-BP878920HU CSB-MP878920HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SMPD3 Peptide (OEEG01140) - OEEG01140 from Aviva Systems Biology Category Peptide Prices $150.00 Sizes 50 µg Source Rabbit Species Human

nSMase2 (C-terminal region) - SX4065 from ECM Biosciences Category Peptide Prices $55.00 Sizes 50 μg

SMPD3 - TP318441 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Sphingomyelin Phosphodiesterase 3, Peptide - MBS396444 from MyBioSource Category Peptide Prices $195.00 Sizes 50 µg Source Rabbit Species Human

SMPD3 Peptide, Human - M34GP14770H from Creative Peptides Category Peptide Source Synthetic. Species Human

Sphingomyelin phosphodiesterase 3 (SMPD3), Recombinant Protein - MBS1327882 from MyBioSource Category Protein Prices $490.00, $655.00, $665.00, $720.00, $820.00, $895.00, $1,005.00, $1,015.00, $1,030.00, $1,055.00, $1,495.00, $1,525.00, $1,615.00, $2,005.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 50 µg (Yeast), 500 µg (E-Coli), 50 µg (Baculovirus), 200 µg (Yeast), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Sphingomyelin phosphodiesterase 3 (SMPD3), Recombinant Protein - MBS7053469 from MyBioSource Category Protein Prices $1,315.00, $1,820.00, $2,725.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression

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