| Gene Symbol | SMPD3 |
|---|---|
| Entrez Gene | 55512 |
| Alt Symbol | NSMASE2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) |
| Other Description | nSMase-2|neutral sphingomyelinase 2|neutral sphingomyelinase II|sphingomyelin phosphodiesterase 3 |
| Swissprots | B7ZL82 Q9NY59 Q2M1S8 |
| Accessions | ACV30039 ADG64729 ADG64730 CAD35076 CCF76927 EAW83233 Q9NY59 AA461272 AJ250460 CAB92964 AK026246 BAB15409 AK289651 BAF82340 AL157660 AW163364 BC012727 BC041828 BC112238 AAI12239 BC143631 AAI43632 BC143634 AAI43635 BI196095 CA424980 CB268111 DQ424899 ABD83664 HQ258353 ADR83107 XM_005256031 XP_005256088 XM_005256032 XP_005256089 XM_011523207 XP_011521509 XM_011523208 XP_011521510 XM_011523209 XP_011521511 XM_011523210 XP_011521512 XR_933371 NM_018667 NP_061137 |
| Function | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. {ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Subcellular Location | Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells. |
| Tissue Specificity | Predominantly expressed in brain. {ECO:0000269|PubMed:10823942}. |
| Top Pathways | Sphingolipid metabolism |