| Gene Symbol |
AK4
|
| Entrez Gene |
205
|
| Alt Symbol |
AK 4, AK3, AK3L1, AK3L2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adenylate kinase 4
|
| Other Description |
AK 4|ATP-AMP transphosphorylase|GTP:AMP phosphotransferase AK4, mitochondrial|adenylate kinase 3-like 1|adenylate kinase 4, mitochondrial|adenylate kinase isoenzyme 4, mitochondrial|mitochondrial adenylate kinase-3|nucleoside-triphosphate-adenylate kinase
|
| Swissprots |
Q6NXQ5 P27144 Q6IBH4 D3DQ62 B2R927 Q8IUU9
|
| Accessions |
CCE45535 EAX06538 EAX06540 EAX06544 P27144 AK025926 AK026966 AK309057 AK313611 BAG36374 BC016180 AAH16180 BC040224 AAH40224 BC066944 AAH66944 BC136886 AAI36887 BC136887 AAI36888 BC146653 AAI46654 BC148270 AAI48271 BF205061 BG703687 BM763432 BU164554 CR456830 CAG33111 DB061266 DQ892294 ABM83220 DQ895494 ABM86420 DR003868 X60673 CAA43088 NM_001005353 NP_001005353 NM_013410 NP_037542 NM_203464 NP_982289
|
| Function |
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|PubMed:19073142, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:23416111}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03170, ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:19766732}.
|
| Tissue Specificity |
Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain. {ECO:0000269|PubMed:11485571}.
|
| Top Pathways |
Purine metabolism
|