ACVR1C

Gene Symbol ACVR1C
Entrez Gene 130399
Alt Symbol ACVRLK7, ALK7
Species Human
Gene Type protein-coding
Description activin A receptor, type IC
Other Description ACTR-IC|ALK-7|activin receptor type IC|activin receptor type-1C|activin receptor-like kinase 7
Swissprots Q8TBG2 Q8NER5 Q86UL2 Q86UL1 Q4ZFZ8
Accessions AAX88951 AAY15093 CAJ33702 CAJ33703 CAJ33704 EAX11444 EAX11445 EAX11446 Q8NER5 AF525679 AAP21993 AF525680 AAP21994 AF525681 AAP21995 AW014016 AY127050 AAM93495 BC022530 AAH22530 BC030101 BI601014 DQ895570 ABM86496 EU176205 ABW03656 NM_001111031 NP_001104501 NM_001111032 NP_001104502 NM_001111033 NP_001104503 NM_145259 NP_660302
Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}.
Subcellular Location Membrane {ECO:0000269|PubMed:12606401}; Single-pass type I membrane protein {ECO:0000269|PubMed:12606401}.
Tissue Specificity Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:12606401}.
Top Pathways TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

ACTR-IC (A-1) - sc-374538 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTR-IC (A-1): sc-374538. Western blot analysis of ACTR-IC expression in T84 (A) and MIA PaCa-2 (B) whole cell lysates.

ACTR-IC (S-19) - sc-54158 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ACTR-IC (D-11) - sc-376905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTR-IC (D-11): sc-376905. Western blot analysis of ACTR-IC expression in MIA PaCa-2 whole cell lysate.

ACTR-IC (H-132) - sc-135001 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ACTR-IC (H-132): sc-135001. Western blot analysis of ACTR-IC expression in JAR whole cell lysate.

ACTR-IC (P-18) - sc-54157 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACTR-IC (P-18): sc-54157. Western blot analysis of ACTR-IC expression in T84 whole cell lysate.

Anti-Activin A Receptor Type IC antibody - ab111121 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of Activin A Receptor Type IC in COS7 cells, using ab111121 at a 1/100 dilution. The imge on the right is from cells treated with the synthesized peptide.

Anti-Activin A Receptor Type IC antibody - ab77051 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Activin A Receptor Type IC antibody (ab77051) at 1 µg/mlLane 2 : Anti-Activin A Receptor Type IC antibody (ab77051) at 2 µg/mlLane 1 : Human placenta lysateLane 2 : Human placenta lysateLysates/proteins at 15 µg per lane.

Anti-Activin A Receptor Type IC antibody - ab76538 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Activin A Receptor Type IC antibody (ab76538) at 1/50 dilution + Hela cell line lysates at 35 µg

Anti-Activin A Receptor Type IC antibody - ab65088 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Activin A Receptor Type IC antibody (ab65088) at 2 µg/ml + Spleen (Human) Tissue Lysate - adult normal tissue (ab29699) at 20 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Activin A Receptor Type IC antibody - ab67921 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Activin A Receptor Type IC antibody (ab67921) at 1/500 dilutionLane 1 : ACVR1C transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat anti-mouse IgG (H&L)-HRP at 1/2000 dilution

Anti-Activin A Receptor Type IC antibody - Aminoterminal end - ab71539 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Activin A Receptor Type IC antibody - Aminoterminal end (ab71539) at 1/100 dilutionLane 1 : HepG2 cell line lysateLane 2 : Hela cell line lysateLysates/proteins at 12.5 µg per lane.

Anti-ACVR1C / ALK7 Antibody - LS-C147050 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACVR1C / ALK7 Antibody (aa340-368, AP) - LS-C232407 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVR1C / ALK7 Antibody (aa340-368, Biotin) - LS-C232408 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVR1C / ALK7 Antibody (aa340-368, APC) - LS-C232409 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVR1C / ALK7 Antibody (aa340-368, FITC) - LS-C232410 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVR1C / ALK7 Antibody (aa340-368, PE) - LS-C232415 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVR1C / ALK7 Antibody (aa340-368, Azide-free, HRP) - LS-C249374 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVR1C / ALK7 Antibody (aa72-121) - LS-C111433 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ACVR1C antibody LS-C111433 Western blot of Fetal Brain lysate.

Anti-ACVR1C / ALK7 Antibody (aa201-250) - LS-C119149 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using ACTR-1C Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ACVR1C / ALK7 Antibody - LS-C306083 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ACVR1C / ALK7 Antibody (aa23-112) - LS-C306096 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ACVR1C / ALK7 Antibody - LS-C309319 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACVR1C / ALK7 Antibody - LS-C192242 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ACVR1C pAb in extracts from 293T cells.

Anti-ACVR1C / ALK7 Antibody (aa340-368) - LS-C329191 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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