ACVR1C
| Gene Symbol | ACVR1C |
|---|---|
| Entrez Gene | 130399 |
| Alt Symbol | ACVRLK7, ALK7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | activin A receptor, type IC |
| Other Description | ACTR-IC|ALK-7|activin receptor type IC|activin receptor type-1C|activin receptor-like kinase 7 |
| Swissprots | Q8TBG2 Q8NER5 Q86UL2 Q86UL1 Q4ZFZ8 |
| Accessions | AAX88951 AAY15093 CAJ33702 CAJ33703 CAJ33704 EAX11444 EAX11445 EAX11446 Q8NER5 AF525679 AAP21993 AF525680 AAP21994 AF525681 AAP21995 AW014016 AY127050 AAM93495 BC022530 AAH22530 BC030101 BI601014 DQ895570 ABM86496 EU176205 ABW03656 NM_001111031 NP_001104501 NM_001111032 NP_001104502 NM_001111033 NP_001104503 NM_145259 NP_660302 |
| Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:12606401}; Single-pass type I membrane protein {ECO:0000269|PubMed:12606401}. |
| Tissue Specificity | Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:12606401}. |
| Top Pathways | TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells |
Activin A Receptor Type IC peptide - ab166744 from Abcam
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Human Activin A Receptor Type IC full length protein - ab132686 from Abcam
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Human Activin A Receptor Type IC peptide - ab74349 from Abcam
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Human Activin A Receptor Type IC protein fragment - ab125628 from Abcam
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Human Activin A Receptor Type IC protein fragment - ab153595 from Abcam
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ACVR1C / ALK7 Antibody Blocking Peptide - LS-E3428 from LifeSpan Bioscience
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ACVR1C / ALK7 Antibody Blocking Peptide - LS-E8692 from LifeSpan Bioscience
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ACVR1C / ALK7 Antibody Blocking Peptide - LS-E19040 from LifeSpan Bioscience
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ACVR1C / ALK7 Antibody Blocking Peptide - LS-E29214 from LifeSpan Bioscience
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ACVR1C / ALK7 Antibody Blocking Peptide - LS-E30569 from LifeSpan Bioscience
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Recombinant Human ALK-7/Activin Receptor Type 1C Protein - H00130399-Q01 from Novus Biologicals
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Recombinant Human ALK-7/Activin Receptor Type 1C Protein - H00130399-P01 from Novus Biologicals
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ACVR1C-Antibody-Center-E271-Blocking-Peptide - BP7102c from Abgent, a WuXi AppTec company
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Activin-A-Receptor-Type-IC-ACVR1C-Antibody-N-term-A48-Blocking-peptide - BP7102a from Abgent, a WuXi AppTec company
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Cynomolgus ALK-7 protein - orb138165 from Biorbyt
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Human ALK-7 (Fc Tag) protein - orb232249 from Biorbyt
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ACVR1C Blocking Peptide - 33R-7772 from Fitzgerald
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ALK 7 Blocking Peptide - 33R-10573 from Fitzgerald
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ALK7 Blocking Peptide - 33R-11011 from Fitzgerald
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Activin receptor type 1C (ACVR1C) - H00130399-P01-10 from Acris Antibodies
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Activin receptor type 1C (ACVR1C) - H00130399-P01-25 from Acris Antibodies
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Activin receptor type 1C (ACVR1C) - H00130399-Q01-10 from Acris Antibodies
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Activin receptor type 1C (ACVR1C) - H00130399-Q01-25 from Acris Antibodies
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Activin receptor type 1C (ACVR1C) Control Peptide - AP30016CP-N from Acris Antibodies
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ACVR1C fusion protein - Ag3162 from Proteintech Group
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