ACVR1C

Gene Symbol	ACVR1C
Entrez Gene	130399
Alt Symbol	ACVRLK7, ALK7
Species	Human
Gene Type	protein-coding
Description	activin A receptor, type IC
Other Description	ACTR-IC|ALK-7|activin receptor type IC|activin receptor type-1C|activin receptor-like kinase 7
Swissprots	Q8TBG2 Q8NER5 Q86UL2 Q86UL1 Q4ZFZ8
Accessions	AAX88951 AAY15093 CAJ33702 CAJ33703 CAJ33704 EAX11444 EAX11445 EAX11446 Q8NER5 AF525679 AAP21993 AF525680 AAP21994 AF525681 AAP21995 AW014016 AY127050 AAM93495 BC022530 AAH22530 BC030101 BI601014 DQ895570 ABM86496 EU176205 ABW03656 NM_001111031 NP_001104501 NM_001111032 NP_001104502 NM_001111033 NP_001104503 NM_145259 NP_660302
Function	Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}.
Subcellular Location	Membrane {ECO:0000269|PubMed:12606401}; Single-pass type I membrane protein {ECO:0000269|PubMed:12606401}.
Tissue Specificity	Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:12606401}.
Top Pathways	TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-ACVR1C-cDNA-Clone - DC05296 from Abgent, a WuXi AppTec company Prices $665.55 Sizes 10 µg Species Human Accession BC022530

ACVR1C - MBS1271606 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC022530

Human ACVR1C cDNA clone(NM_001111031.1) - CDFH000282 from Creative Biomart Species Human Accession NM_001111031.1

Human ACVR1C cDNA clone(NM_001111032.1) - CDFH000283 from Creative Biomart Species Human Accession NM_001111032.1

Human ACVR1C cDNA clone(NM_001111033.1) - CDFH000284 from Creative Biomart Species Human Accession NM_001111033.1

Human ACVR1C ORF Clone(NM_001111031.1) - CDCL153082 from Creative Biomart Species Human Accession NM_001111031.1

Human ACVR1C ORF Clone(NM_001111031.1) - CDCR347804 from Creative Biomart Species Human Accession NM_001111031.1

Human ACVR1C ORF Clone(NM_001111031.1) - CDCR347805 from Creative Biomart Species Human Accession NM_001111031.1

Human ACVR1C ORF Clone(NM_001111032.1) - CDCR347806 from Creative Biomart Species Human Accession NM_001111032.1

Human ACVR1C ORF Clone(NM_001111032.1) - CDCR347807 from Creative Biomart Species Human Accession NM_001111032.1

Human ACVR1C ORF Clone(NM_001111033.1) - CDCR347808 from Creative Biomart Species Human Accession NM_001111033.1

Human ACVR1C ORF Clone(NM_001111033.1) - CDCR347809 from Creative Biomart Species Human Accession NM_001111033.1

Human ALK-7 / ACVR1C Gene ORF cDNA clone in cloning vector - HG10869-M from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10869-CM from Sino Biological Species Human

Human ACVR1C / ALK-7 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10869-M-F from Sino Biological Species Human Accession NM_145259.2

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid - HG10869-M-N from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid, N-His tag - HG10869-NH from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid, N-HA tag - HG10869-NY from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid, C-His tag - HG10869-CH from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10869-ACR from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10869-ACG from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid - HG10869-UT from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10869-NF from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10869-NM from Sino Biological Species Human

Human ALK-7 / ACVR1C Gene ORF cDNA clone expression plasmid, C-HA tag - HG10869-CY from Sino Biological Species Human

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