| Gene Symbol |
ACVR1C
|
| Entrez Gene |
130399
|
| Alt Symbol |
ACVRLK7, ALK7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
activin A receptor, type IC
|
| Other Description |
ACTR-IC|ALK-7|activin receptor type IC|activin receptor type-1C|activin receptor-like kinase 7
|
| Swissprots |
Q8TBG2 Q8NER5 Q86UL2 Q86UL1 Q4ZFZ8
|
| Accessions |
AAX88951 AAY15093 CAJ33702 CAJ33703 CAJ33704 EAX11444 EAX11445 EAX11446 Q8NER5 AF525679 AAP21993 AF525680 AAP21994 AF525681 AAP21995 AW014016 AY127050 AAM93495 BC022530 AAH22530 BC030101 BI601014 DQ895570 ABM86496 EU176205 ABW03656 NM_001111031 NP_001104501 NM_001111032 NP_001104502 NM_001111033 NP_001104503 NM_145259 NP_660302
|
| Function |
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:12606401}; Single-pass type I membrane protein {ECO:0000269|PubMed:12606401}.
|
| Tissue Specificity |
Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:12606401}.
|
| Top Pathways |
TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells
|