ACVR1C
| Gene Symbol | ACVR1C |
|---|---|
| Entrez Gene | 130399 |
| Alt Symbol | ACVRLK7, ALK7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | activin A receptor, type IC |
| Other Description | ACTR-IC|ALK-7|activin receptor type IC|activin receptor type-1C|activin receptor-like kinase 7 |
| Swissprots | Q8TBG2 Q8NER5 Q86UL2 Q86UL1 Q4ZFZ8 |
| Accessions | AAX88951 AAY15093 CAJ33702 CAJ33703 CAJ33704 EAX11444 EAX11445 EAX11446 Q8NER5 AF525679 AAP21993 AF525680 AAP21994 AF525681 AAP21995 AW014016 AY127050 AAM93495 BC022530 AAH22530 BC030101 BI601014 DQ895570 ABM86496 EU176205 ABW03656 NM_001111031 NP_001104501 NM_001111032 NP_001104502 NM_001111033 NP_001104503 NM_145259 NP_660302 |
| Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:12606401}; Single-pass type I membrane protein {ECO:0000269|PubMed:12606401}. |
| Tissue Specificity | Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:12606401}. |
| Top Pathways | TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells |
ACTR-IC CRISPR/Cas9 KO Plasmid (h) - sc-402173 from Santa Cruz Biotechnology
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ACTR-IC HDR Plasmid (h) - sc-402173-HDR from Santa Cruz Biotechnology
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ACTR-IC Double Nickase Plasmid (h) - sc-402173-NIC from Santa Cruz Biotechnology
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ACTR-IC Double Nickase Plasmid (h2) - sc-402173-NIC-2 from Santa Cruz Biotechnology
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ACTR-IC CRISPR Activation Plasmid (h) - sc-402173-ACT from Santa Cruz Biotechnology
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ACTR-IC CRISPR Activation Plasmid (h2) - sc-402173-ACT-2 from Santa Cruz Biotechnology
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ACTR-IC Lentiviral Activation Particles (h) - sc-402173-LAC from Santa Cruz Biotechnology
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ACTR-IC Lentiviral Activation Particles (h2) - sc-402173-LAC-2 from Santa Cruz Biotechnology
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ACTR-IC siRNA (h) - sc-72337 from Santa Cruz Biotechnology
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ACTR-IC shRNA Plasmid (h) - sc-72337-SH from Santa Cruz Biotechnology
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ACTR-IC shRNA (h) Lentiviral Particles - sc-72337-V from Santa Cruz Biotechnology
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ALK-7/Activin Receptor Type 1C RNAi - H00130399-R04 from Novus Biologicals
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MISSION® esiRNA - EHU145721 from Sigma-Aldrich
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MISSION® siRNA - SIHK0032 from Sigma-Aldrich
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MISSION® siRNA - SIHK0033 from Sigma-Aldrich
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MISSION® siRNA - SIHK0039 from Sigma-Aldrich
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MISSION® siRNA - SIHK0038 from Sigma-Aldrich
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MISSION® siRNA - SIHK0034 from Sigma-Aldrich
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MISSION® siRNA - SIHK0036 from Sigma-Aldrich
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MISSION® siRNA - SIHK0037 from Sigma-Aldrich
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MISSION® siRNA - SIHK0035 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2795 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2795 from Sigma-Aldrich
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ACVR1C siRNA (Human) - CRJ5029 from Cohesion Biosciences
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ACVR1C - MBS8231005 from MyBioSource
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