NCK1

Gene Symbol NCK1
Entrez Gene 4690
Alt Symbol NCK, NCKalpha, nck-1
Species Human
Gene Type protein-coding
Description NCK adaptor protein 1
Other Description NCK tyrosine kinase|SH2/SH3 adaptor protein NCK-alpha|cytoplasmic protein NCK1|melanoma NCK protein|non-catalytic region of tyrosine kinase
Swissprots D3DNE3 P16333 B7Z751
Accessions EAW79105 EAW79106 EAW79107 EAW79108 EAW79109 P16333 AK095534 AK301460 BAH13487 AK312692 BAG35571 BC006403 AAH06403 BP339594 DA265476 DA855124 DB117533 DQ893094 ABM84020 EU832672 ACE87763 EU832751 ACE87083 X17576 CAA35599 NM_001190796 NP_001177725 NM_001291999 NP_001278928 NM_006153 NP_006144
Function Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.
Subcellular Location Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
Top Pathways Axon guidance, T cell receptor signaling pathway, Pathogenic Escherichia coli infection, ErbB signaling pathway

Cytoplasmic protein NCK1 (NCK1), Human, ELISA Kit - E01C2359 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7207440 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7226909 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7247650 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7206183 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7215152 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7249537 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7234434 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7243174 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7232727 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7221468 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7251164 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytoplasmic protein NCK1 (NCK1), ELISA Kit - MBS7234038 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Custom Human NCK1 ELISA - ELH-NCK1-1 from RayBiotech

Category ELISA Kit
Prices $627.00, $1,128.60, $2,508.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human NCK1 ELISA Kit - orb384674 from Biorbyt

Category ELISA Kit
Prices $1,411.00, $2,448.00, $5,321.00
Sizes 96 assays, 192 assays, 480 assays

Human NCK1 ELISA Kit - E011237 from Biobool

Category ELISA Kit

anti-Nck antibody [NC-20 (20B-1H9)] - ARG62564 from Arigo Biolaboratories

Category ELISA Kit
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