NCK1

Gene Symbol	NCK1
Entrez Gene	4690
Alt Symbol	NCK, NCKalpha, nck-1
Species	Human
Gene Type	protein-coding
Description	NCK adaptor protein 1
Other Description	NCK tyrosine kinase|SH2/SH3 adaptor protein NCK-alpha|cytoplasmic protein NCK1|melanoma NCK protein|non-catalytic region of tyrosine kinase
Swissprots	D3DNE3 P16333 B7Z751
Accessions	EAW79105 EAW79106 EAW79107 EAW79108 EAW79109 P16333 AK095534 AK301460 BAH13487 AK312692 BAG35571 BC006403 AAH06403 BP339594 DA265476 DA855124 DB117533 DQ893094 ABM84020 EU832672 ACE87763 EU832751 ACE87083 X17576 CAA35599 NM_001190796 NP_001177725 NM_001291999 NP_001278928 NM_006153 NP_006144
Function	Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.
Subcellular Location	Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
Top Pathways	Axon guidance, T cell receptor signaling pathway, Pathogenic Escherichia coli infection, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nck full length protein - ab172816 from Abcam Category Protein Source E. coli Species Human

Human Nck full length protein - ab85711 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Nck full length protein - ab97409 from Abcam Category Protein Source E. coli Species Human

NCK1 / NCK Antibody Blocking Peptide - LS-E2652 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NCK1 / NCK Antibody Blocking Peptide - LS-E23514 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NCK1 / NCK Antibody Blocking Peptide - LS-E9802 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NCK1 Recombinant Protein - H00004690-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NCK1 Partial Recombinant Protein - H00004690-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NCK1 Protein - NBP1-45253 from Novus Biologicals Category Protein Prices $279.00 Sizes 100 µg Species Human

NCK1-Antibody-N-term-Blocking-peptide - BP13726a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NCK1-Antibody-N-term-Blocking-Peptide - BP8825a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NCK1 Recombinant Protein - GTX48172-PRO from GeneTex Category Protein Prices $329.00 Sizes 50 μg Source E. coli Species Human

NCK1 Protein (OPPA02334) - OPPA02334 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human NCK Adaptor Protein 1 protein - orb81230 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli

Human NCK1 protein - orb163486 from Biorbyt Category Protein Prices $289.00, $553.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

NCK1 protein - 30R-3031 from Fitzgerald Category Protein Prices $295.00 Sizes 200 µg Source E.coli

NCK1 protein (His tag) - 80R-1350 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

NCK1 (1-377, His-tag) - AR09524PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

NCK1 (1-377, His-tag) - AR09524PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

NCK1 - H00004690-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NCK1 - H00004690-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NCK1 - H00004690-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NCK1 - H00004690-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NCK1, 1-377aa, Human, His tag, E.coli - 01-NCK1 from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NCK1, Human, Recombinant - 19-CF49 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source E. coli Species Human

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