NCK1

Gene Symbol	NCK1
Entrez Gene	4690
Alt Symbol	NCK, NCKalpha, nck-1
Species	Human
Gene Type	protein-coding
Description	NCK adaptor protein 1
Other Description	NCK tyrosine kinase|SH2/SH3 adaptor protein NCK-alpha|cytoplasmic protein NCK1|melanoma NCK protein|non-catalytic region of tyrosine kinase
Swissprots	D3DNE3 P16333 B7Z751
Accessions	EAW79105 EAW79106 EAW79107 EAW79108 EAW79109 P16333 AK095534 AK301460 BAH13487 AK312692 BAG35571 BC006403 AAH06403 BP339594 DA265476 DA855124 DB117533 DQ893094 ABM84020 EU832672 ACE87763 EU832751 ACE87083 X17576 CAA35599 NM_001190796 NP_001177725 NM_001291999 NP_001278928 NM_006153 NP_006144
Function	Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.
Subcellular Location	Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
Top Pathways	Axon guidance, T cell receptor signaling pathway, Pathogenic Escherichia coli infection, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NCK1-Over-expression-Lysate - LY11471a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

NCK1 293T Cell Transient Overexpression Lysate(Denatured) - H00004690-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

NCK1 overexpression lysate - LY416832 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

NCK1 overexpression lysate - LY434154 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

NCK1 293 Cell Lysate - 407867 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

NCK1 Overexpression Lysate (Denatured) - H00004690-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

NCK1 (h3): 293T Lysate - sc-177605 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

NCK1 Over-expression Lysate Product - GWB-65A499 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

NCK1 Overexpression Lysate (Native) - NBP2-10428 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human NCK1 Knockdown Stable Cell Line - CSC-DC010184 from Creative biogene Category Cell Line Species Human

NCK1 Knockout Cell Line-HeLa - CSC-RT1852 from Creative biogene Category Cell Line Species Human

NCK1 KO Cell Lysate-HeLa - CLKO-1701 from Creative biogene Category Cell Lysate

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