| Gene Symbol |
NCK1
|
| Entrez Gene |
4690
|
| Alt Symbol |
NCK, NCKalpha, nck-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NCK adaptor protein 1
|
| Other Description |
NCK tyrosine kinase|SH2/SH3 adaptor protein NCK-alpha|cytoplasmic protein NCK1|melanoma NCK protein|non-catalytic region of tyrosine kinase
|
| Swissprots |
D3DNE3 P16333 B7Z751
|
| Accessions |
EAW79105 EAW79106 EAW79107 EAW79108 EAW79109 P16333 AK095534 AK301460 BAH13487 AK312692 BAG35571 BC006403 AAH06403 BP339594 DA265476 DA855124 DB117533 DQ893094 ABM84020 EU832672 ACE87763 EU832751 ACE87083 X17576 CAA35599 NM_001190796 NP_001177725 NM_001291999 NP_001278928 NM_006153 NP_006144
|
| Function |
Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.
|
| Subcellular Location |
Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
|
| Top Pathways |
Axon guidance, T cell receptor signaling pathway, Pathogenic Escherichia coli infection, ErbB signaling pathway
|