| Gene Symbol | GCNT1 |
|---|---|
| Entrez Gene | 2650 |
| Alt Symbol | C2GNT, C2GNT-L, C2GNT1, G6NT, NACGT2, NAGCT2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glucosaminyl (N-acetyl) transferase 1, core 2 |
| Other Description | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N--acetylglucosaminyltransferase|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase|beta-1,6-N-acetylglucosaminyltransferase|core 2 GnT|core 2 beta-1,6-N-acetylglucosaminyltransferase I|core 2 beta1,6 N-acetylglucosaminyltransferase-I|core 2 branching enzyme|core 2-branching enzyme|core2-GlcNAc-transferase|glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase) |
| Swissprots | Q6DJZ4 Q02742 |
| Accessions | AAA96661 EAW62580 Q02742 AI445628 AJ420416 AK313343 BAG36146 AL832647 CAD89956 AY196293 AY196294 AY196295 AY196296 AY196297 BC074885 AAH74885 BC074886 AAH74886 BC109101 AAI09102 BC109102 AAI09103 BP359964 DA479942 M97347 AAA35919 XM_006717052 XP_006717115 NM_001097633 NP_001091102 NM_001097634 NP_001091103 NM_001097635 NP_001091104 NM_001097636 NP_001091105 NM_001490 NP_001481 |
| Function | Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O- glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. {ECO:0000269|PubMed:23027862}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:23027862}; Single-pass type II membrane protein {ECO:0000269|PubMed:23027862}. Note=Also detected in the trans-Golgi network. |
| Tissue Specificity | Highly expressed in activated T-lymphocytes and myeloid cells. |
| Top Pathways | Mucin type O-Glycan biosynthesis |
Human GCNT1 cDNA clone(NM_001097633.1) - CDFH007446 from Creative Biomart
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Human GCNT1 cDNA clone(NM_001097634.1) - CDFH007447 from Creative Biomart
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Human GCNT1 cDNA clone(NM_001097635.1) - CDFH007448 from Creative Biomart
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Human GCNT1 cDNA clone(NM_001097636.1) - CDFH007449 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001490.4) - CDCL164472 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001097633.1) - CDCR346275 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001097633.1) - CDCR346276 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001097634.1) - CDCR346277 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001097634.1) - CDCR346278 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001097635.1) - CDCR346279 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001097635.1) - CDCR346280 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001097636.1) - CDCR346411 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001097636.1) - CDCR346412 from Creative Biomart
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Human GCNT1 ORF Clone(NM_001097634.1) - CDCR346277 from Creative biogene
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Human GCNT1 ORF Clone(NM_001097635.1) - CDCR346279 from Creative biogene
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Human GCNT1 ORF Clone(NM_001097636.1) - CDCR346411 from Creative biogene
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Mouse GCNT1 ORF clone (NM_001097633.1) - CDCL111047 from Creative biogene
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Human GCNT1 cDNA Clone(NM_001097633.1) - CDFH007446 from Creative biogene
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Human GCNT1 cDNA Clone(NM_001097634.1) - CDFH007447 from Creative biogene
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Human GCNT1 cDNA Clone(NM_001097635.1) - CDFH007448 from Creative biogene
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Human GCNT1 cDNA Clone(NM_001097636.1) - CDFH007449 from Creative biogene
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