| Gene Symbol |
RGS2
|
| Entrez Gene |
5997
|
| Alt Symbol |
G0S8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
regulator of G-protein signaling 2
|
| Other Description |
G0 to G1 switch regulatory 8, 24kD|G0/G1 switch regulatory protein 8|cell growth-inhibiting gene 31 protein|cell growth-inhibiting protein 31|regulator of G-protein signaling 2, 24kDa
|
| Swissprots |
Q6I9U5 P41220
|
| Accessions |
AAA20680 EAW91231 EAW91232 P41220 AF493926 AAM12640 AK313668 BAG36420 AY971351 AAY40361 BC007049 AAH07049 BC042755 AAH42755 BC044742 BI912389 BT007065 AAP35728 CD700013 CR457410 CAG33691 DQ893178 ABM84104 DQ896478 ABM87477 L13463 AAC37587 NM_002923 NP_002914
|
| Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199, ECO:0000269|PubMed:19736320, ECO:0000269|PubMed:7643615}.
|
| Subcellular Location |
Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus.
|
| Tissue Specificity |
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). {ECO:0000269|PubMed:7643615}.
|
| Top Pathways |
Oxytocin signaling pathway, cGMP-PKG signaling pathway
|
