Grem1
| Gene Symbol | Grem1 |
|---|---|
| Entrez Gene | 23892 |
| Alt Symbol | Cktsf1b1, Drm, Grem, ld |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | gremlin 1 |
| Other Description | cysteine knot superfamily 1, BMP antagonist 1|down-regulated in Mos-transformed cells protein|down-regulated in v-mos-transformed cells|gremlin-1 |
| Swissprots | O70326 |
| Accessions | AAD54057 EDL27855 O70326 AF045801 AAC40111 AF108189 AAD54056 AK080776 AK135022 BAE22388 AK148693 AK157737 AK157793 BAE34201 AK164871 BAE37950 BC015293 AAH15293 BY151119 XM_006499444 XP_006499507 NM_011824 NP_035954 |
| Function | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis. {ECO:0000269|PubMed:12808456, ECO:0000269|PubMed:15133038, ECO:0000269|PubMed:15201225}. |
| Subcellular Location | Secreted {ECO:0000305}. |
| Tissue Specificity | Highly expressed in spleen and to a lesser extent in lung, skeletal muscle and kidney. Expressed only in non- transformed cells or primary fibroblasts in culture but not in established transformed or tumor derived cell lines. Broadly expressed in limb bud mesenchyme but restricted to the distal limb bud mesenchyme and concentrated posteriorly. Expressed in ovary especially in granulosa cells of follicles of type 4. {ECO:0000269|PubMed:10965135, ECO:0000269|PubMed:12808456, ECO:0000269|PubMed:15133038}. |
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