GEMIN7

Gene Symbol GEMIN7
Entrez Gene 79760
Alt Symbol SIP3
Species Human
Gene Type protein-coding
Description gem (nuclear organelle) associated protein 7
Other Description gem-associated protein 7|gemin 7|gemin-7
Swissprots Q9H840 Q6IA34
Accessions CAE91216 EAW57321 Q9H840 AK024018 BAB14780 AY114106 AAM44083 BC007793 AAH07793 BU602037 CB148876 CR457321 CAG33602 W35331 XM_005259262 XP_005259319 XM_005259263 XP_005259320 XM_005259264 XP_005259321 XM_011527319 XP_011525621 NM_001007269 NP_001007270 NM_001007270 NP_001007271 NM_024707 NP_078983
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:12065586, ECO:0000269|PubMed:18984161}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:12065586}. Nucleus, gem {ECO:0000269|PubMed:12065586}. Cytoplasm {ECO:0000269|PubMed:12065586}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways RNA transport

Gemin7 (5F1) - sc-130668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Gemin7 (M-111) - sc-368684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Gemin7 (M-111): sc-368684. Western blot analysis of Gemin7 expression in ES-D3 whole cell lysate (A) and mouse thymus tissue extract (B).

Gemin7 (P-19) - sc-67496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Gemin 7 antibody - ab102042 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Gemin 7 antibody (ab102042) at 1/500 dilution + Mouse kidney tissue lysate at 50 µg

Anti-Gemin 7 antibody - ab32681 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Gemin 7 antibody - ab57779 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57779 Gemin 7 antibody at 1ug/ml.

Anti-Gemin 7 antibody - ab172667 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Gemin 7 antibody (ab172667) at 1/500 dilutionLane 1 : Gemin 7 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-Gemin 7 antibody - ab172685 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Gemin 7 antibody (ab172685) at 1/500 dilutionLane 1 : Gemin 7 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-Gemin 7 antibody - N-terminal - ab186904 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Gemin 7 antibody - N-terminal (ab186904) at 1 µg/ml + MCF7 whole cell lysate at 10 µg

Anti-GEMIN7 Antibody - LS-C307676 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GEMIN7 Antibody - LS-C310473 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GEMIN7 Antibody (HRP) - LS-C318471 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GEMIN7 Antibody (FITC) - LS-C318472 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GEMIN7 Antibody (Biotin) - LS-C318938 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GEMIN7 Antibody (aa1-50) - LS-C206195 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GEMIN7 antibody Western Blot of MCF7. Antibody dilution: 1 ug/ml.

Anti-GEMIN7 Antibody - LS-C318475 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Gem-associated protein 7 antibody at 2 ug/ml. lane 1: HeLa whole cell lysate. lane 2: 293T whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:10000 dilution. Predicted band size: 15.

Gemin 7 Antibody - H00079760-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Gemin 7 Antibody [H00079760-D01P] - Analysis of GEMIN7 expression in mouse kidney.

Gemin 7 Antibody - H00079760-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Gemin 7 Antibody (2E2) - H00079760-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E2
Sandwich ELISA: Gemin 7 Antibody (2E2) [H00079760-M01] - Detection limit for recombinant GST tagged GEMIN7 is approximately 0.3ng/ml as a capture antibody.

Gemin 7 Antibody - H00079760-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Gemin 7 Antibody [H00079760-B01] - analysis of GEMIN7 expression in transfected 293T cell line by GEMIN7 MaxPab polyclonal antibody (B01). Lane 1: GEMIN7 transfected lysate (14.52 KDa). Lane 2: Non-transfected lysate.

Gemin 7 Antibody - H00079760-B02 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Gemin 7 Antibody [H00079760-B02] - analysis of GEMIN7 expression in transfected 293T cell line by GEMIN7 MaxPab polyclonal antibody (B02). Lane 1: GEMIN7 transfected lysate (14.50 KDa). Lane 2: Non-transfected lysate.

Gemin 7 Antibody (4H6) - H00079760-M09 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4H6

Gemin 7 Polyclonal Antibody - bs-13330R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Gemin 7 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13330R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Gemin 7 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13330R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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