GEMIN7

Gene Symbol GEMIN7
Entrez Gene 79760
Alt Symbol SIP3
Species Human
Gene Type protein-coding
Description gem (nuclear organelle) associated protein 7
Other Description gem-associated protein 7|gemin 7|gemin-7
Swissprots Q9H840 Q6IA34
Accessions CAE91216 EAW57321 Q9H840 AK024018 BAB14780 AY114106 AAM44083 BC007793 AAH07793 BU602037 CB148876 CR457321 CAG33602 W35331 XM_005259262 XP_005259319 XM_005259263 XP_005259320 XM_005259264 XP_005259321 XM_011527319 XP_011525621 NM_001007269 NP_001007270 NM_001007270 NP_001007271 NM_024707 NP_078983
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:12065586, ECO:0000269|PubMed:18984161}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:12065586}. Nucleus, gem {ECO:0000269|PubMed:12065586}. Cytoplasm {ECO:0000269|PubMed:12065586}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways RNA transport

Human-GEMIN7-cDNA-Clone - DC02256 from Abgent, a WuXi AppTec company

Prices $176.85
Sizes 10 µg
Species Human
Accession BC007793

GEMIN7 - MBS1270230 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC007793

Human GEMIN7 cDNA clone(NM_024707.2) - CDFG004421 from Creative Biomart

Species Human
Accession NM_024707.2

Human GEMIN7 cDNA clone(NM_001007270.1) - CDFH007488 from Creative Biomart

Species Human
Accession NM_001007270.1

Human GEMIN7 cDNA clone(NM_001007269.1) - CDFH007489 from Creative Biomart

Species Human
Accession NM_001007269.1

Human GEMIN7 ORF Clone(NM_024707.2) - CDCL164540 from Creative Biomart

Species Human
Accession NM_024707.2

Human GEMIN7 ORF Clone(NM_024707.2) - CDCR309509 from Creative Biomart

Species Human
Accession NM_024707.2

Human GEMIN7 ORF Clone(NM_024707.2) - CDCR309510 from Creative Biomart

Species Human
Accession NM_024707.2

Human GEMIN7 ORF Clone(NM_001007269.1) - CDCR340248 from Creative Biomart

Species Human
Accession NM_001007269.1

Human GEMIN7 ORF Clone(NM_001007269.1) - CDCR340249 from Creative Biomart

Species Human
Accession NM_001007269.1

Human GEMIN7 ORF Clone(NM_001007270.1) - CDCR340250 from Creative Biomart

Species Human
Accession NM_001007270.1

Human GEMIN7 ORF Clone(NM_001007270.1) - CDCR340251 from Creative Biomart

Species Human
Accession NM_001007270.1

Human GEMIN7 ORF Clone(NM_024707.2) - CDCR309509 from Creative biogene

Species Human

Human GEMIN7 ORF Clone(NM_001007269.1) - CDCR340248 from Creative biogene

Species Human

Human GEMIN7 ORF Clone(NM_001007270.1) - CDCR340250 from Creative biogene

Species Human

Human GEMIN7 ORF Clone (BC007793) - CDCS406327 from Creative biogene

Species Human
Accession Q9H840

Human GEMIN7 cDNA Clone(NM_024707.2) - CDFG004421 from Creative biogene

Species Human

Human GEMIN7 cDNA Clone(NM_001007270.1) - CDFH007488 from Creative biogene

Species Human

Human GEMIN7 cDNA Clone(NM_001007269.1) - CDFH007489 from Creative biogene

Species Human
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