GEMIN7
| Gene Symbol | GEMIN7 |
|---|---|
| Entrez Gene | 79760 |
| Alt Symbol | SIP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | gem (nuclear organelle) associated protein 7 |
| Other Description | gem-associated protein 7|gemin 7|gemin-7 |
| Swissprots | Q9H840 Q6IA34 |
| Accessions | CAE91216 EAW57321 Q9H840 AK024018 BAB14780 AY114106 AAM44083 BC007793 AAH07793 BU602037 CB148876 CR457321 CAG33602 W35331 XM_005259262 XP_005259319 XM_005259263 XP_005259320 XM_005259264 XP_005259321 XM_011527319 XP_011525621 NM_001007269 NP_001007270 NM_001007270 NP_001007271 NM_024707 NP_078983 |
| Function | The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:12065586, ECO:0000269|PubMed:18984161}. |
| Subcellular Location | Nucleus, nucleoplasm {ECO:0000269|PubMed:12065586}. Nucleus, gem {ECO:0000269|PubMed:12065586}. Cytoplasm {ECO:0000269|PubMed:12065586}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. |
| Top Pathways | RNA transport |
Gemin7 CRISPR/Cas9 KO Plasmid (h) - sc-408279 from Santa Cruz Biotechnology
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Gemin7 HDR Plasmid (h) - sc-408279-HDR from Santa Cruz Biotechnology
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Gemin7 Double Nickase Plasmid (h) - sc-408279-NIC from Santa Cruz Biotechnology
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Gemin7 Double Nickase Plasmid (h2) - sc-408279-NIC-2 from Santa Cruz Biotechnology
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Gemin7 CRISPR Activation Plasmid (h) - sc-408279-ACT from Santa Cruz Biotechnology
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Gemin7 CRISPR Activation Plasmid (h2) - sc-408279-ACT-2 from Santa Cruz Biotechnology
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Gemin7 Lentiviral Activation Particles (h) - sc-408279-LAC from Santa Cruz Biotechnology
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Gemin7 Lentiviral Activation Particles (h2) - sc-408279-LAC-2 from Santa Cruz Biotechnology
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Gemin7 siRNA (h) - sc-62370 from Santa Cruz Biotechnology
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Gemin7 shRNA Plasmid (h) - sc-62370-SH from Santa Cruz Biotechnology
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Gemin7 shRNA (h) Lentiviral Particles - sc-62370-V from Santa Cruz Biotechnology
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Gemin 7 RNAi - H00079760-R02 from Novus Biologicals
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Gemin 7 RNAi - H00079760-R03 from Novus Biologicals
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MISSION® esiRNA - EHU105151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9232 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9232 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12510 from Sigma-Aldrich
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GEMIN7 siRNA (Human) - CRJ2546 from Cohesion Biosciences
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Gemin 7 RNAi - H00079760-R01 from Novus Biologicals
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GEMIN7 - MBS8227241 from MyBioSource
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shRNA set against Human GEMIN7 (NM_024707.2) - SHH300498 from Creative biogene
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shRNA set against Human GEMIN7(NM_001007269.1) - SHH082055 from Creative biogene
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Human GEMIN7 siRNA - orb273047 from Biorbyt
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GEMIN7 shRNA Plasmid (Human) - CHJ2546 from Cohesion Biosciences
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GEMIN7 miRNA 3'UTR clone - MiUTR1H-04008 from Creative biogene
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