GEMIN7

Gene Symbol	GEMIN7
Entrez Gene	79760
Alt Symbol	SIP3
Species	Human
Gene Type	protein-coding
Description	gem (nuclear organelle) associated protein 7
Other Description	gem-associated protein 7|gemin 7|gemin-7
Swissprots	Q9H840 Q6IA34
Accessions	CAE91216 EAW57321 Q9H840 AK024018 BAB14780 AY114106 AAM44083 BC007793 AAH07793 BU602037 CB148876 CR457321 CAG33602 W35331 XM_005259262 XP_005259319 XM_005259263 XP_005259320 XM_005259264 XP_005259321 XM_011527319 XP_011525621 NM_001007269 NP_001007270 NM_001007270 NP_001007271 NM_024707 NP_078983
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:12065586, ECO:0000269|PubMed:18984161}.
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:12065586}. Nucleus, gem {ECO:0000269|PubMed:12065586}. Cytoplasm {ECO:0000269|PubMed:12065586}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GEMIN7-Over-expression-Lysate - LY14280a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

GEMIN7 293T Cell Transient Overexpression Lysate(Denatured) - H00079760-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GEMIN7 293T Cell Transient Overexpression Lysate(Denatured) - H00079760-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GEMIN7 overexpression lysate - LY411163 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GEMIN7 overexpression lysate - LY423478 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GEMIN7 overexpression lysate - LY423479 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GEMIN7 overexpression lysate - LY425221 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GEMIN7 overexpression lysate - LY425222 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GEMIN7 293 Cell Lysate - 405610 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Gemin 7 Overexpression Lysate (Denatured) - H00079760-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

Gemin 7 Overexpression Lysate (Denatured) - H00079760-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Gemin 7 Overexpression Lysate (Native) - NBL1-11039 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

GEMIN7 Over-expression Lysate Product - GWB-75A0E7 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Gemin 7 Overexpression Lysate (Native) - NBP2-10757 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Gemin 7 Overexpression Lysate (Native) - NBP2-10756 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Gemin 7 Overexpression Lysate (Native) - NBP2-11184 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Gemin 7 Overexpression Lysate (Native) - NBP2-11183 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Gemin 7 Overexpression Lysate (Denatured) - H00079760-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human GEMIN7 Knockdown Stable Cell Line - CSC-DC006208 from Creative biogene Category Cell Line Species Human

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