| Gene Symbol |
DDX58
|
| Entrez Gene |
23586
|
| Alt Symbol |
RIG-I, RIGI, RLR-1, SGMRT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
|
| Other Description |
DEAD box protein 58|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|RNA helicase RIG-I|probable ATP-dependent RNA helicase DDX58|retinoic acid-inducible gene 1 protein|retinoic acid-inducible gene I protein
|
| Swissprots |
Q5VYT1 O95786 Q9NT04 Q5HYE1 A2RU81
|
| Accessions |
CCQ43430 EAW58547 EAW58548 O95786 AA862613 AF038963 AAD19826 AK023661 BAG51213 AK125989 BAG54273 AK301678 BAG63151 AK315040 AL137608 CAB70840 BC070029 BC107731 AAI07732 BC132786 AAI32787 BC136610 AAI36611 BX647917 CAI46068 DN998145 NM_014314 NP_055129
|
| Function |
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK- related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs)
|
| Subcellular Location |
Cytoplasm. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell junction, tight junction. Note=Colocalized with TRIM25 at cytoplasmic perinuclear bodies. Associated with the actin cytoskeleton at membrane ruffles.
|
| Tissue Specificity |
Present in vascular smooth cells (at protein level). {ECO:0000269|PubMed:15219805}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Measles, Influenza A
|