DDX58

Gene Symbol	DDX58
Entrez Gene	23586
Alt Symbol	RIG-I, RIGI, RLR-1, SGMRT2
Species	Human
Gene Type	protein-coding
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Other Description	DEAD box protein 58|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|RNA helicase RIG-I|probable ATP-dependent RNA helicase DDX58|retinoic acid-inducible gene 1 protein|retinoic acid-inducible gene I protein
Swissprots	Q5VYT1 O95786 Q9NT04 Q5HYE1 A2RU81
Accessions	CCQ43430 EAW58547 EAW58548 O95786 AA862613 AF038963 AAD19826 AK023661 BAG51213 AK125989 BAG54273 AK301678 BAG63151 AK315040 AL137608 CAB70840 BC070029 BC107731 AAI07732 BC132786 AAI32787 BC136610 AAI36611 BX647917 CAI46068 DN998145 NM_014314 NP_055129
Function	Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK- related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs)
Subcellular Location	Cytoplasm. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell junction, tight junction. Note=Colocalized with TRIM25 at cytoplasmic perinuclear bodies. Associated with the actin cytoskeleton at membrane ruffles.
Tissue Specificity	Present in vascular smooth cells (at protein level). {ECO:0000269|PubMed:15219805}.
Top Pathways	RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DDX58 full length protein - ab132502 from Abcam Category Protein Source Wheat germ Species Human

Human DDX58 peptide - ab65587 from Abcam Category Peptide

Human DDX58 peptide - ab23038 from Abcam Category Peptide Species Human

DDX58 / RIG-1 / RIG-I Antibody Blocking Peptide - LS-E6319 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX58 / RIG-1 / RIG-I Antibody Blocking Peptide - LS-E6320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX58 / RIG-1 / RIG-I Antibody Blocking Peptide - LS-E13044 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RIG-I Protein - H00023586-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

RIG-I Peptide - P0643 from Novus Biologicals Category Peptide Species Human

RIG-I Peptide - P0642 from Novus Biologicals Category Peptide Species Human

RIG-I-Antibody-Center-Blocking-Peptide - BP1900c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIG-I-Antibody-C-term-Blocking-Peptide - BP1900a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human DDX58 protein - orb244159 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

DDX58 Blocking Peptide - 33R-2340 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human RIG1 Protein - abx068877 from Abbexa Category Protein Source E.coli Species Human

DDX58 - H00023586-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DDX58 - H00023586-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DDX58 fusion protein - ag18585 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DDX58 fusion protein - Ag18591 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human DDX58, GST-tagged - DDX58-10H from Creative Biomart Category Protein Source wheat germ

Recombinant Human DDX58, MYC/DDK-tagged - DDX58-11H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Retinoic Acid Inducible Gene 1 Protein (RIG1) - RPB532Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Retinoic Acid Inducible Gene 1 Protein (RIG1) - RPB532Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Retinoic Acid Inducible Gene 1 Protein (RIG1) - RPB532Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Probable ATP-dependent RNA helicase DDX58(DDX58) ,partial - CSB-YP006638HU CSB-BP006638HU CSB-MP006638HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Probable ATP-dependent RNA helicase DDX58 - CSB-EP006638HU from Cusabio Category Protein Source E.coli Species Human

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