CORIN

Gene Symbol CORIN
Entrez Gene 10699
Alt Symbol ATC2, CRN, Lrp4, PEE5, TMPRSS10
Species Human
Gene Type protein-coding
Description corin, serine peptidase
Other Description atrial natriuretic peptide-converting enzyme|heart-specific serine proteinase ATC2|pro-ANP-convertase|pro-ANP-converting enzyme|transmembrane protease serine 10
Swissprots Q4W5E5 Q2TBD2 Q4W5G6 B0ZBE3 Q9Y5Q5 Q9UHY2
Accessions AAN40016 AAY40917 AAY40991 ACA05911 EAW93038 EAW93039 Q9Y5Q5 AF113248 AAF21966 AF133845 AAD31850 AI338960 AI378383 AI872582 AK297675 BAH12647 AK302816 BAG64015 AK304038 BAG64949 AK304466 BAG65281 BC110451 AAI10452 BX648285 NM_001278585 NP_001265514 NM_001278586 NP_001265515 NM_006587 NP_006578
Function Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Subcellular Location Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.
Tissue Specificity Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level). {ECO:0000269|PubMed:10329693, ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:22437503}.

Corin (N-15) - sc-47850 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Corin (N-15): sc-47850. Western blot analysis of Corin expression in human skeletal muscle tissue extract.

Corin (D-15) - sc-47849 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Corin (T-15) - sc-47852 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Corin (H-220) - sc-67178 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Corin (H-220): sc-67178. Western blot analysis of Corin expression in HeLa whole cell lysate.

Corin (M-225) - sc-67179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Corin (M-225): sc-67179. Western blot analysis of Corin expression in HeLa whole cell lysate.

Corin (D-25) - sc-133475 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Corin antibody - ab71951 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Corin antibody (ab71951) at 1/500 dilutionLane 1 : Mouse heart tissue whole cell lysateLane 2 : Rat heart tissue whole cell lysate

Anti-Corin antibody - ab56131 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Corin antibody (ab56131) at 1/1000 dilutionLane 1 : Cells transfected with human CorinLane 2 : Control transfectionLysates/proteins at 10 µl per lane.

Anti-Corin antibody - ab56983 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56983 LRP4 antibody at 1ug/ml.

Anti-Corin antibody - ab56158 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Corin antibody (ab56158) at 1/1000 dilutionLane 1 : Whole cell lysate prepared from cells transfected with human CorinLane 2 : Whole cell lysate - control transfectionLysates/proteins at 10 µl per lane.

Anti-Corin antibody - ab56159 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Corin antibody (ab56159) at 1/1000 dilutionLane 1 : Whole cell lysate prepared from cells transfected with human CorinLane 2 : Whole cell lysate - control transfectionLysates/proteins at 10 µl per lane.

Anti-Corin antibody - ab56130 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (Internal, AP) - LS-C218740 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (Internal, FITC) - LS-C218744 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (Internal, Biotin) - LS-C218741 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (Internal, Azide-free, HRP) - LS-C218745 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (Internal, PE) - LS-C218746 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (Internal, APC) - LS-C221195 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (aa533-634, Biotin) - LS-C300343 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (aa881-930) - LS-C80928 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.

Anti-CORIN Antibody (aa616-716) - LS-C307820 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CORIN Antibody (aa533-634, FITC) - LS-C302094 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (Internal) - LS-C327008 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CORIN Antibody (aa467-497) - LS-C166953 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CORIN Antibody in mouse heart tissue lysates (35 ug/lane). CORIN (arrow) was detected using the purified antibody.

Anti-CORIN Antibody (aa334-477) - LS-C293531 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant CORIN.
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