| Gene Symbol |
CORIN
|
| Entrez Gene |
10699
|
| Alt Symbol |
ATC2, CRN, Lrp4, PEE5, TMPRSS10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
corin, serine peptidase
|
| Other Description |
atrial natriuretic peptide-converting enzyme|heart-specific serine proteinase ATC2|pro-ANP-convertase|pro-ANP-converting enzyme|transmembrane protease serine 10
|
| Swissprots |
Q4W5E5 Q2TBD2 Q4W5G6 B0ZBE3 Q9Y5Q5 Q9UHY2
|
| Accessions |
AAN40016 AAY40917 AAY40991 ACA05911 EAW93038 EAW93039 Q9Y5Q5 AF113248 AAF21966 AF133845 AAD31850 AI338960 AI378383 AI872582 AK297675 BAH12647 AK302816 BAG64015 AK304038 BAG64949 AK304466 BAG65281 BC110451 AAI10452 BX648285 NM_001278585 NP_001265514 NM_001278586 NP_001265515 NM_006587 NP_006578
|
| Function |
Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
|
| Subcellular Location |
Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.
|
| Tissue Specificity |
Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level). {ECO:0000269|PubMed:10329693, ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:22437503}.
|