CORIN
| Gene Symbol | CORIN |
|---|---|
| Entrez Gene | 10699 |
| Alt Symbol | ATC2, CRN, Lrp4, PEE5, TMPRSS10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | corin, serine peptidase |
| Other Description | atrial natriuretic peptide-converting enzyme|heart-specific serine proteinase ATC2|pro-ANP-convertase|pro-ANP-converting enzyme|transmembrane protease serine 10 |
| Swissprots | Q4W5E5 Q2TBD2 Q4W5G6 B0ZBE3 Q9Y5Q5 Q9UHY2 |
| Accessions | AAN40016 AAY40917 AAY40991 ACA05911 EAW93038 EAW93039 Q9Y5Q5 AF113248 AAF21966 AF133845 AAD31850 AI338960 AI378383 AI872582 AK297675 BAH12647 AK302816 BAG64015 AK304038 BAG64949 AK304466 BAG65281 BC110451 AAI10452 BX648285 NM_001278585 NP_001265514 NM_001278586 NP_001265515 NM_006587 NP_006578 |
| Function | Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. |
| Subcellular Location | Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage. |
| Tissue Specificity | Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level). {ECO:0000269|PubMed:10329693, ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:22437503}. |
Mouse CORIN ELISA Kit (Sandwich ELISA) - LS-F6784 from LifeSpan Bioscience
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Human CORIN ELISA Kit (Sandwich ELISA) - LS-F2935 from LifeSpan Bioscience
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Human CORIN ELISA Kit (Sandwich ELISA) - LS-F6649 from LifeSpan Bioscience
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Human CORIN ELISA Kit (Sandwich ELISA) - LS-F692 from LifeSpan Bioscience
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Rat CORIN ELISA Kit (Sandwich ELISA) - LS-F9358 from LifeSpan Bioscience
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Human CORIN ELISA Kit (Sandwich ELISA) - LS-F11179 from LifeSpan Bioscience
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Human Corin Quantikine ELISA Kit - DCRN00 from R&D Systems
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Human Corin DuoSet ELISA - DY2209 from R&D Systems
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Quantikine Immunoassay Control Set 841 for Human Corin - QC67 from R&D Systems
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Corin ELISA Kit (Human) : 96 Wells (OKAG00213) - OKAG00213 from Aviva Systems Biology
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Human Corin ELISA Kit - abx051288 from Abbexa
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Human Corin ELISA Kit - abx151156 from Abbexa
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Human CORIN ELISA Kit - abx056119 from Abbexa
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Atrial natriuretic peptide-converting enzyme, CORIN, Human, ELISA Kit - E1930h from ARP American Research Products
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Corin (Atrial natriuretic peptide-converting enzyme), Human, ELISA Kit - E01C0019 from ARP American Research Products
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Corin (CRN), Human, ELISA Kit - SEG316Hu from ARP American Research Products
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Corin, Human, ELISA Kit - CSB-E17447h from ARP American Research Products
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Corin, CRN, Human, ELISA Kit - E-EL-H0042 from ARP American Research Products
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Corin, CRN, Rabbit, ELISA Kit - E-EL-RB1584 from ARP American Research Products
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Corin, CRN, Chicken, ELISA Kit - E-EL-Ch1038 from ARP American Research Products
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Corin, CRN, Porcine, ELISA Kit - E-EL-P0868 from ARP American Research Products
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Corin, CRN, Sheep, ELISA Kit - E-EL-S0099 from ARP American Research Products
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Corin, CRN, Guinea Pig, ELISA Kit - E-EL-GP0362 from ARP American Research Products
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Corin, CRN, Monkey, ELISA Kit - E-EL-MK0381 from ARP American Research Products
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corin, serine peptidase, ELISA Kit - MBS930583 from MyBioSource
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