CORIN

Gene Symbol CORIN
Entrez Gene 10699
Alt Symbol ATC2, CRN, Lrp4, PEE5, TMPRSS10
Species Human
Gene Type protein-coding
Description corin, serine peptidase
Other Description atrial natriuretic peptide-converting enzyme|heart-specific serine proteinase ATC2|pro-ANP-convertase|pro-ANP-converting enzyme|transmembrane protease serine 10
Swissprots Q4W5E5 Q2TBD2 Q4W5G6 B0ZBE3 Q9Y5Q5 Q9UHY2
Accessions AAN40016 AAY40917 AAY40991 ACA05911 EAW93038 EAW93039 Q9Y5Q5 AF113248 AAF21966 AF133845 AAD31850 AI338960 AI378383 AI872582 AK297675 BAH12647 AK302816 BAG64015 AK304038 BAG64949 AK304466 BAG65281 BC110451 AAI10452 BX648285 NM_001278585 NP_001265514 NM_001278586 NP_001265515 NM_006587 NP_006578
Function Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Subcellular Location Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.
Tissue Specificity Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level). {ECO:0000269|PubMed:10329693, ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:22437503}.

Corin CRISPR/Cas9 KO Plasmid (h) - sc-404362 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Corin HDR Plasmid (h) - sc-404362-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Corin Double Nickase Plasmid (h) - sc-404362-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Corin Double Nickase Plasmid (h2) - sc-404362-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Corin CRISPR Activation Plasmid (h) - sc-404362-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Corin CRISPR Activation Plasmid (h2) - sc-404362-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Corin Lentiviral Activation Particles (h) - sc-404362-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Corin Lentiviral Activation Particles (h2) - sc-404362-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Corin siRNA (h) - sc-60432 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Corin shRNA Plasmid (h) - sc-60432-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Corin shRNA (h) Lentiviral Particles - sc-60432-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Corin RNAi - H00010699-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU014651 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6451 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6451 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10317 from Sigma-Aldrich

Category miRNA

CORIN siRNA (Human) - CRH7295 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CORIN - MBS827871 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CORIN (NM_006587.2) - SHH268033 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CORIN(NM_006587.2) - SHG193411 from Creative biogene

Category siRNA
Species Reactivities Human

CORIN shRNA Plasmid (Human) - CHH7295 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CORIN miRNA 3'UTR clone - MiUTR1H-02369 from Creative biogene

Species Reactivities Human
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