CORIN
| Gene Symbol | CORIN |
|---|---|
| Entrez Gene | 10699 |
| Alt Symbol | ATC2, CRN, Lrp4, PEE5, TMPRSS10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | corin, serine peptidase |
| Other Description | atrial natriuretic peptide-converting enzyme|heart-specific serine proteinase ATC2|pro-ANP-convertase|pro-ANP-converting enzyme|transmembrane protease serine 10 |
| Swissprots | Q4W5E5 Q2TBD2 Q4W5G6 B0ZBE3 Q9Y5Q5 Q9UHY2 |
| Accessions | AAN40016 AAY40917 AAY40991 ACA05911 EAW93038 EAW93039 Q9Y5Q5 AF113248 AAF21966 AF133845 AAD31850 AI338960 AI378383 AI872582 AK297675 BAH12647 AK302816 BAG64015 AK304038 BAG64949 AK304466 BAG65281 BC110451 AAI10452 BX648285 NM_001278585 NP_001265514 NM_001278586 NP_001265515 NM_006587 NP_006578 |
| Function | Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. |
| Subcellular Location | Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage. |
| Tissue Specificity | Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level). {ECO:0000269|PubMed:10329693, ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:22437503}. |
Human Corin protein fragment - ab153116 from Abcam
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Mouse Corin peptide - ab197636 from Abcam
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CORIN Antibody Blocking Peptide - LS-E17003 from LifeSpan Bioscience
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CORIN Antibody Blocking Peptide - LS-E8514 from LifeSpan Bioscience
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Recombinant Human Corin Protein - H00010699-Q01 from Novus Biologicals
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CORIN-Antibody-Center-Blocking-Peptide - BP6868c from Abgent, a WuXi AppTec company
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CORIN Blocking Peptide - 33R-3817 from Fitzgerald
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Human Corin Protein - abx066119 from Abbexa
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Human Corin Protein - abx066120 from Abbexa
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Human Corin Protein - abx066123 from Abbexa
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CORIN - H00010699-Q01-10 from Acris Antibodies
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CORIN - H00010699-Q01-25 from Acris Antibodies
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CORIN control peptide - AP10194CP-N from Acris Antibodies
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CORIN fusion protein - ag15898 from Proteintech Group
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CORIN fusion protein - Ag17059 from Proteintech Group
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Recombinant Human CORIN - CORIN-745H from Creative Biomart
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Recombinant Corin (CRN) - RPG316Hu01 from Uscn Life Science Inc.
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Recombinant Corin (CRN) - RPG316Hu02 from Uscn Life Science Inc.
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Recombinant Corin (CRN) - RPG316Hu03 from Uscn Life Science Inc.
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Recombinant Corin (CRN) - RPG316Hu04 from Uscn Life Science Inc.
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Recombinant Corin (CRN) - RPG316Mu01 from Uscn Life Science Inc.
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Recombinant Corin (CRN) - RPG316Mu02 from Uscn Life Science Inc.
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Recombinant Corin (CRN) - RPG316Ra01 from Uscn Life Science Inc.
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Recombinant Corin (CRN) - RPG316Hu01 from Cloud-clone
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Recombinant Corin (CRN) - RPG316Hu02 from Cloud-clone
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