| Gene Symbol |
MATK
|
| Entrez Gene |
4145
|
| Alt Symbol |
CHK, CTK, HHYLTK, HYL, HYLTK, Lsk
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
megakaryocyte-associated tyrosine kinase
|
| Other Description |
CSK homologous kinase|Csk-homologous kinase|Csk-type protein tyrosine kinase|HYL tyrosine kinase|hematopoietic consensus tyrosine-lacking kinase|hydroxyaryl-protein kinase|leukocyte carboxyl-terminal src kinase related|megakaryocyte-associated tyrosine-protein kinase|protein kinase HYL|tyrosine kinase MATK|tyrosine-protein kinase CTK|tyrosylprotein kinase
|
| Swissprots |
Q9NST8 B3KNZ9 P42679
|
| Accessions |
AAC60645 AAC62843 EAW69284 EAW69285 EAW69286 EAW69287 P42679 AB593100 BAJ84040 AK055395 BAG51511 AK225834 AK315646 BAG38013 AL137754 CAB70906 BC000114 AAH00114 BC003109 AAH03109 BG396388 BM925586 BQ109562 DA592994 L18974 AAA16703 S71669 AAB30995 X77278 CAA54493 XM_011528018 XP_011526320 XM_011528019 XP_011526321 NM_002378 NP_002369 NM_139354 NP_647611 NM_139355 NP_647612
|
| Function |
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. {ECO:0000269|PubMed:9171348}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9171348}. Membrane {ECO:0000269|PubMed:9171348}. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
|
| Tissue Specificity |
Expressed in various myeloid cell lines, detected in brain and lung.
|
| Top Pathways |
Neurotrophin signaling pathway
|