MATK
| Gene Symbol | MATK |
|---|---|
| Entrez Gene | 4145 |
| Alt Symbol | CHK, CTK, HHYLTK, HYL, HYLTK, Lsk |
| Species | Human |
| Gene Type | protein-coding |
| Description | megakaryocyte-associated tyrosine kinase |
| Other Description | CSK homologous kinase|Csk-homologous kinase|Csk-type protein tyrosine kinase|HYL tyrosine kinase|hematopoietic consensus tyrosine-lacking kinase|hydroxyaryl-protein kinase|leukocyte carboxyl-terminal src kinase related|megakaryocyte-associated tyrosine-protein kinase|protein kinase HYL|tyrosine kinase MATK|tyrosine-protein kinase CTK|tyrosylprotein kinase |
| Swissprots | Q9NST8 B3KNZ9 P42679 |
| Accessions | AAC60645 AAC62843 EAW69284 EAW69285 EAW69286 EAW69287 P42679 AB593100 BAJ84040 AK055395 BAG51511 AK225834 AK315646 BAG38013 AL137754 CAB70906 BC000114 AAH00114 BC003109 AAH03109 BG396388 BM925586 BQ109562 DA592994 L18974 AAA16703 S71669 AAB30995 X77278 CAA54493 XM_011528018 XP_011526320 XM_011528019 XP_011526321 NM_002378 NP_002369 NM_139354 NP_647611 NM_139355 NP_647612 |
| Function | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. {ECO:0000269|PubMed:9171348}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9171348}. Membrane {ECO:0000269|PubMed:9171348}. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation. |
| Tissue Specificity | Expressed in various myeloid cell lines, detected in brain and lung. |
| Top Pathways | Neurotrophin signaling pathway |
Lsk CRISPR/Cas9 KO Plasmid (h) - sc-403533 from Santa Cruz Biotechnology
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Lsk HDR Plasmid (h) - sc-403533-HDR from Santa Cruz Biotechnology
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Lsk Double Nickase Plasmid (h) - sc-403533-NIC from Santa Cruz Biotechnology
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Lsk Double Nickase Plasmid (h2) - sc-403533-NIC-2 from Santa Cruz Biotechnology
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Lsk CRISPR Activation Plasmid (h) - sc-403533-ACT from Santa Cruz Biotechnology
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Lsk CRISPR Activation Plasmid (h2) - sc-403533-ACT-2 from Santa Cruz Biotechnology
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Lsk Lentiviral Activation Particles (h) - sc-403533-LAC from Santa Cruz Biotechnology
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Lsk Lentiviral Activation Particles (h2) - sc-403533-LAC-2 from Santa Cruz Biotechnology
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Lsk siRNA (h) - sc-38973 from Santa Cruz Biotechnology
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Lsk shRNA Plasmid (h) - sc-38973-SH from Santa Cruz Biotechnology
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Lsk shRNA (h) Lentiviral Particles - sc-38973-V from Santa Cruz Biotechnology
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MATK RNAi - H00004145-R06 from Novus Biologicals
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MISSION® esiRNA - EHU084441 from Sigma-Aldrich
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MISSION® siRNA - SIHK1275 from Sigma-Aldrich
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MISSION® siRNA - SIHK1276 from Sigma-Aldrich
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MISSION® siRNA - SIHK1277 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13061 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01191 from Sigma-Aldrich
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MATK siRNA (Human) - CRH2818 from Cohesion Biosciences
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MATK RNAi - H00004145-R04 from Novus Biologicals
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MATK RNAi - H00004145-R05 from Novus Biologicals
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shRNA set against Human MATK (NM_002378.3) - SHH338599 from Creative biogene
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shRNA set against Human MATK(NM_139355.2) - SHH178519 from Creative biogene
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shRNA set against Human MATK(NM_002378.3) - SHH178553 from Creative biogene
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