BBC3

Gene Symbol	BBC3
Entrez Gene	27113
Alt Symbol	JFY-1, JFY1, PUMA
Species	Human
Gene Type	protein-coding
Description	BCL2 binding component 3
Other Description	bcl-2-binding component 3|p53 up-regulated modulator of apoptosis
Swissprots	B9EGI3 Q9BXH1 Q96PG8 O00171 Q96PG9
Accessions	EAW57465 EAW57466 EAW57467 Q96PG8 Q9BXH1 AA887822 AF332558 AAK31316 AF354654 AAK39542 AF354655 AAK39543 AF354656 AAK39544 AK124984 AK298837 BAG60965 BC136481 AAI36482 BG258126 U82987 AAB51243 XM_006723141 XP_006723204 XM_011526722 XP_011525024 XM_011526723 XP_011525025 NM_001127240 NP_001120712 NM_001127241 NP_001120713 NM_001127242 NP_001120714 NM_014417 NP_055232
Function	Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:11463392, ECO:0000269|PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11463391}.
Top Pathways	p53 signaling pathway, Huntington's disease, Measles, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BBC3 / PUMA ELISA Kit (Sandwich ELISA) - LS-F5715 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Rat BBC3 / PUMA ELISA Kit (Sandwich ELISA) - LS-F6590 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.047 ng/ml Range 0.156-10 ng/ml

Bcl-2-binding component 3, BBC3, Human, ELISA Kit - E1909h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

p53 Upregulated Modulator Of Apoptosis (PUMA), Human, ELISA Kit - SEB909Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.048ng/mL Range 0.156-10ng/mL

P53 Upregulated Modulator of Apoptosis, PUMA, Human, ELISA Kit - E-EL-H1439 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

P53 Upregulated Modulator of Apoptosis, PUMA, Rat, ELISA Kit - E-EL-R0712 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

P53 Upregulated Modulator of Apoptosis, PUMA, Rabbit, ELISA Kit - E-EL-RB0488 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

P53 Upregulated Modulator of Apoptosis, PUMA, Chicken, ELISA Kit - E-EL-Ch1873 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

P53 Upregulated Modulator of Apoptosis, PUMA, Porcine, ELISA Kit - E-EL-P1566 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

P53 Upregulated Modulator of Apoptosis, PUMA, Sheep, ELISA Kit - E-EL-S0527 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

P53 Upregulated Modulator of Apoptosis, PUMA, Guinea Pig, ELISA Kit - E-EL-GP0685 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

P53 Upregulated Modulator of Apoptosis, PUMA, Monkey, ELISA Kit - E-EL-MK0681 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human PUMA ELISA Kit - HP0752 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human PUMA(P53 Upregulated Modulator of Apoptosis) ELISA Kit - E-EL-H1439 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human PUMA (P53 Upregulated Modulator of Apoptosis) CLIA Kit - E-CL-H0924 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) - SEB909Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) - SEB909Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.047ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human P53 Upregulated Modulator Of Apoptosis ELISA - E01P0745 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) - SEB909Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat BBC3 / PUMA ELISA Kit (Custom ELISA) - LS-F18789 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse BBC3 / PUMA ELISA Kit (Custom ELISA) - LS-F18788 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human BBC3 / PUMA ELISA Kit (Custom ELISA) - LS-F18790 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human MSTN(Myostatin) ELISA Kit - E-EL-H1439 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human PUMA ELISA Kit - abx152900 from Abbexa Category ELISA Kit Sensitivity 0.048 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human BBC3 / PUMA ELISA Kit (Sandwich ELISA) - LS-F21103 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

Search more