| Gene Symbol |
BBC3
|
| Entrez Gene |
27113
|
| Alt Symbol |
JFY-1, JFY1, PUMA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BCL2 binding component 3
|
| Other Description |
bcl-2-binding component 3|p53 up-regulated modulator of apoptosis
|
| Swissprots |
B9EGI3 Q9BXH1 Q96PG8 O00171 Q96PG9
|
| Accessions |
EAW57465 EAW57466 EAW57467 Q96PG8 Q9BXH1 AA887822 AF332558 AAK31316 AF354654 AAK39542 AF354655 AAK39543 AF354656 AAK39544 AK124984 AK298837 BAG60965 BC136481 AAI36482 BG258126 U82987 AAB51243 XM_006723141 XP_006723204 XM_011526722 XP_011525024 XM_011526723 XP_011525025 NM_001127240 NP_001120712 NM_001127241 NP_001120713 NM_001127242 NP_001120714 NM_014417 NP_055232
|
| Function |
Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:11463392, ECO:0000269|PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11463391}.
|
| Top Pathways |
p53 signaling pathway, Huntington's disease, Measles, Hippo signaling pathway
|
![Western Blot: PUMA Overexpression Lysate (Adult Normal) [NBL1-07925] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PUMA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6675_PUMA%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07925-img0002.jpg)
![Western Blot: PUMA Overexpression Lysate (Adult Normal) [NBP2-11377] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PUMA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3918_PUMA%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11377-img0001.jpg)