BBC3

Gene Symbol	BBC3
Entrez Gene	27113
Alt Symbol	JFY-1, JFY1, PUMA
Species	Human
Gene Type	protein-coding
Description	BCL2 binding component 3
Other Description	bcl-2-binding component 3|p53 up-regulated modulator of apoptosis
Swissprots	B9EGI3 Q9BXH1 Q96PG8 O00171 Q96PG9
Accessions	EAW57465 EAW57466 EAW57467 Q96PG8 Q9BXH1 AA887822 AF332558 AAK31316 AF354654 AAK39542 AF354655 AAK39543 AF354656 AAK39544 AK124984 AK298837 BAG60965 BC136481 AAI36482 BG258126 U82987 AAB51243 XM_006723141 XP_006723204 XM_011526722 XP_011525024 XM_011526723 XP_011525025 NM_001127240 NP_001120712 NM_001127241 NP_001120713 NM_001127242 NP_001120714 NM_014417 NP_055232
Function	Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:11463392, ECO:0000269|PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11463391}.
Top Pathways	p53 signaling pathway, Huntington's disease, Measles, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Puma siRNA I - 12845 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Puma siRNA II - 12890 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

PUMA siRNA (h) - sc-37153 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PUMAα shRNA Plasmid (h) - sc-37153-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PUMAα shRNA (h) Lentiviral Particles - sc-37153-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU093341 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1592 from Sigma-Aldrich Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1592 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07655 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07655

BBC3 siRNA (Human) - CRH8971 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BBC3 siRNA (Human) - CRH8972 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BBC3 - MBS8216448 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BBC3 - MBS8234167 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human BBC3 (NM_014417.4) - SHH245074 from Creative biogene Category siRNA Species Reactivities Human

Human BBC3 siRNA - orb269473 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BBC3 shRNA Plasmid (Human) - CHH8971 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

BBC3 shRNA Plasmid (Human) - CHH8972 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

BBC3 miRNA 3'UTR clone - MiUTR4H-TG00737 from Creative biogene Species Reactivities Human

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