BBC3

Gene Symbol	BBC3
Entrez Gene	27113
Alt Symbol	JFY-1, JFY1, PUMA
Species	Human
Gene Type	protein-coding
Description	BCL2 binding component 3
Other Description	bcl-2-binding component 3|p53 up-regulated modulator of apoptosis
Swissprots	B9EGI3 Q9BXH1 Q96PG8 O00171 Q96PG9
Accessions	EAW57465 EAW57466 EAW57467 Q96PG8 Q9BXH1 AA887822 AF332558 AAK31316 AF354654 AAK39542 AF354655 AAK39543 AF354656 AAK39544 AK124984 AK298837 BAG60965 BC136481 AAI36482 BG258126 U82987 AAB51243 XM_006723141 XP_006723204 XM_011526722 XP_011525024 XM_011526723 XP_011525025 NM_001127240 NP_001120712 NM_001127241 NP_001120713 NM_001127242 NP_001120714 NM_014417 NP_055232
Function	Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:11463392, ECO:0000269|PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11463391}.
Top Pathways	p53 signaling pathway, Huntington's disease, Measles, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PUMA peptide - ab9644 from Abcam Category Peptide Species Human

Human PUMA peptide - ab9646 from Abcam Category Peptide Species Human

Human PUMA peptide - ab32320 from Abcam Category Peptide

BBC3 / PUMA Antibody Blocking Peptide - LS-E2249 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BBC3 / PUMA Antibody Blocking Peptide - LS-E2969 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BBC3 / PUMA Antibody Blocking Peptide - LS-E27491 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BBC3 / PUMA Antibody Blocking Peptide - LS-E21567 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BBC3 / PUMA Antibody Blocking Peptide - LS-E30000 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BBC3 / PUMA Antibody Blocking Peptide - LS-E30001 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PUMA Blocking Peptide - NB500-261PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

PUMA Blocking Peptide - NBP1-76639PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PUMA Blocking Peptide - NBP1-76654PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Puma-BH3-Domain-Antibody-Blocking-Peptide - BP1317a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BBC3-Antibody-Center-Blocking-peptide - BP14100c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PUMA-BH3 - SP2201b from Abgent, a WuXi AppTec company Category Peptide Prices $185.00 Sizes 1 mg

PUMA-BH3 - SP2201a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 500 µg

PUMA Fragment Recombinant Protein - GTX48024-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source E. coli Species Human

PUMA peptide - GTX29644 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

PUMA peptide - GTX29646 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

BBC3 Immunizing peptide - orb59936 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

BBC3 Blocking Peptide - 33R-9339 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PUMA Blocking Peptide - 33R-10712 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

PUMA Blocking Peptide - abx063818 from Abbexa Category Peptide Species Human

PUMA Peptide - AC21-2314-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PUMA Control Peptide - AP30701CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

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