PHLDA3

Gene Symbol PHLDA3
Entrez Gene 23612
Alt Symbol TIH1
Species Human
Gene Type protein-coding
Description pleckstrin homology-like domain, family A, member 3
Other Description TDAG51/Ipl homolog 1|pleckstrin homology-like domain family A member 3|pleckstrin homology-like domain, family A, member 2
Swissprots Q53HD6 Q8NBW9 B2R5A4 Q9Y5J5
Accessions EAW91369 Q9Y5J5 AF151100 AAD42081 AI083980 AI188803 AI624156 AI678238 AI870979 AK075179 BAC11454 AK222644 BAD96364 AK312115 BAG35051 AW194162 AW513769 BC014390 AAH14390 BC068273 AAH68273 BE778799 BE892338 BG990425 BM996951 BQ000725 BX090314 CA406398 CN356697 JF432856 ADZ16073 N94465 W30744 NM_012396 NP_036528 NR_073080
Function p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. {ECO:0000269|PubMed:19203586}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19203586}. Membrane {ECO:0000269|PubMed:19203586}; Peripheral membrane protein {ECO:0000269|PubMed:19203586}.
Tissue Specificity Widely expressed with lowest expression in liver and spleen. {ECO:0000269|PubMed:10594239}.

Pleckstrin homology-like domain family A member 3 (PHLDA3), Human, ELISA Kit - CSB-EL017932HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Pleckstrin homology-like domain family A member 3, ELISA Kit - MBS281204 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

pleckstrin homology-like domain, family A, member 3, ELISA Kit - MBS902699 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 6.25 pg/ml.
Range 25 pg/ml-1600 pg/ml.

Human Pleckstrin homology-like domain family A member 3(PHLDA3) ELISA kit - CSB-EL017932HU from Cusabio

Category ELISA Kit
Sensitivity 6.25pg/ml
Range Request Information

Human Pleckstrin homology-like domain family A member 3(PHLDA3) ELISA Kit - EKC35056 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,287.50
Sizes 96 t, 5x96t, 10x96t
Sensitivity Request Information
Range Request Information

Human PHLDA3 ELISA Kit - E029860 from Biobool

Category ELISA Kit
Sensitivity 6.25 pg/ml.

anti-PHLDA3 / TIH1 antibody - ARG63641 from Arigo Biolaboratories

Category ELISA Kit
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