PHLDA3

Gene Symbol PHLDA3
Entrez Gene 23612
Alt Symbol TIH1
Species Human
Gene Type protein-coding
Description pleckstrin homology-like domain, family A, member 3
Other Description TDAG51/Ipl homolog 1|pleckstrin homology-like domain family A member 3|pleckstrin homology-like domain, family A, member 2
Swissprots Q53HD6 Q8NBW9 B2R5A4 Q9Y5J5
Accessions EAW91369 Q9Y5J5 AF151100 AAD42081 AI083980 AI188803 AI624156 AI678238 AI870979 AK075179 BAC11454 AK222644 BAD96364 AK312115 BAG35051 AW194162 AW513769 BC014390 AAH14390 BC068273 AAH68273 BE778799 BE892338 BG990425 BM996951 BQ000725 BX090314 CA406398 CN356697 JF432856 ADZ16073 N94465 W30744 NM_012396 NP_036528 NR_073080
Function p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. {ECO:0000269|PubMed:19203586}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19203586}. Membrane {ECO:0000269|PubMed:19203586}; Peripheral membrane protein {ECO:0000269|PubMed:19203586}.
Tissue Specificity Widely expressed with lowest expression in liver and spleen. {ECO:0000269|PubMed:10594239}.

PHLDA3 CRISPR/Cas9 KO Plasmid (h) - sc-411773 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHLDA3 HDR Plasmid (h) - sc-411773-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHLDA3 Double Nickase Plasmid (h) - sc-411773-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHLDA3 Double Nickase Plasmid (h2) - sc-411773-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHLDA3 CRISPR Activation Plasmid (h) - sc-411773-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHLDA3 CRISPR Activation Plasmid (h2) - sc-411773-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHLDA3 Lentiviral Activation Particles (h) - sc-411773-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHLDA3 Lentiviral Activation Particles (h2) - sc-411773-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHLDA3 siRNA (h) - sc-78630 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PHLDA3 shRNA Plasmid (h) - sc-78630-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PHLDA3 shRNA (h) Lentiviral Particles - sc-78630-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN16745 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16745 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06161 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06161

PHLDA3 siRNA (Human) - CRH8396 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PHLDA3 (NM_012396.3) - SHH374952 from Creative biogene

Category siRNA
Species Reactivities Human

Human PHLDA3 siRNA - orb268898 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PHLDA3 shRNA Plasmid (Human) - CHH8396 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PHLDA3 miRNA 3'UTR clone - MiUTR1H-07870 from Creative biogene

Species Reactivities Human
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