PHLDA3

Gene Symbol	PHLDA3
Entrez Gene	23612
Alt Symbol	TIH1
Species	Human
Gene Type	protein-coding
Description	pleckstrin homology-like domain, family A, member 3
Other Description	TDAG51/Ipl homolog 1|pleckstrin homology-like domain family A member 3|pleckstrin homology-like domain, family A, member 2
Swissprots	Q53HD6 Q8NBW9 B2R5A4 Q9Y5J5
Accessions	EAW91369 Q9Y5J5 AF151100 AAD42081 AI083980 AI188803 AI624156 AI678238 AI870979 AK075179 BAC11454 AK222644 BAD96364 AK312115 BAG35051 AW194162 AW513769 BC014390 AAH14390 BC068273 AAH68273 BE778799 BE892338 BG990425 BM996951 BQ000725 BX090314 CA406398 CN356697 JF432856 ADZ16073 N94465 W30744 NM_012396 NP_036528 NR_073080
Function	p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. {ECO:0000269|PubMed:19203586}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19203586}. Membrane {ECO:0000269|PubMed:19203586}; Peripheral membrane protein {ECO:0000269|PubMed:19203586}.
Tissue Specificity	Widely expressed with lowest expression in liver and spleen. {ECO:0000269|PubMed:10594239}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PHLDA3 full length protein - ab132274 from Abcam Category Protein Source Wheat germ Species Human

Human PHLDA3 peptide - ab45560 from Abcam Category Peptide Species Human

Human PHLDA3 protein fragment - ab161714 from Abcam Category Protein Source Wheat germ Species Human

PHLDA3 Antibody Blocking Peptide - LS-E25640 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PHLDA3 Antibody Blocking Peptide - LS-E19795 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PHLDA3 Protein - H00023612-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PHLDA3 Protein - H00023612-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PHLDA3/TIH1 blocking peptide - GTX89684-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

PHLDA3 Blocking Peptide - 33R-5324 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PHLDA3 Peptide - AC21-0471-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PHLDA3 - H00023612-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PHLDA3 - H00023612-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PHLDA3 - H00023612-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PHLDA3 - H00023612-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PHLDA3 Peptide - 46-179P from ProSci Category Peptide Species Human

PHLDA3 fusion protein - ag8718 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PHLDA3 fusion protein - Ag8886 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PHLDA3, GST-tagged - PHLDA3-1689H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Pleckstrin homology-like domain family A member 3(PHLDA3) - CSB-YP896737HU CSB-EP896737HU CSB-BP896737HU CSB-MP896737HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PHLDA3 - TP306751 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Pleckstrin homology-like domain family A member 3 (PHLDA3), Recombinant Protein - MBS1346743 from MyBioSource Category Protein Prices $865.00, $865.00, $1,090.00, $1,090.00, $1,255.00, $1,255.00, $1,710.00, $1,710.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PHLDA3/TIH1, Peptide - MBS426003 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

PHLDA3 Recombinant Protein Antigen - NBP1-80683PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PHLDA3 Blocking Peptide - abx061269 from Abbexa Category Peptide Species Human, Mouse, Rat

PHLDA3 Peptide, Human - M34GP11715H from Creative Peptides Category Peptide Source Synthetic. Species Human

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