| Gene Symbol |
PHLDA3
|
| Entrez Gene |
23612
|
| Alt Symbol |
TIH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology-like domain, family A, member 3
|
| Other Description |
TDAG51/Ipl homolog 1|pleckstrin homology-like domain family A member 3|pleckstrin homology-like domain, family A, member 2
|
| Swissprots |
Q53HD6 Q8NBW9 B2R5A4 Q9Y5J5
|
| Accessions |
EAW91369 Q9Y5J5 AF151100 AAD42081 AI083980 AI188803 AI624156 AI678238 AI870979 AK075179 BAC11454 AK222644 BAD96364 AK312115 BAG35051 AW194162 AW513769 BC014390 AAH14390 BC068273 AAH68273 BE778799 BE892338 BG990425 BM996951 BQ000725 BX090314 CA406398 CN356697 JF432856 ADZ16073 N94465 W30744 NM_012396 NP_036528 NR_073080
|
| Function |
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. {ECO:0000269|PubMed:19203586}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19203586}. Membrane {ECO:0000269|PubMed:19203586}; Peripheral membrane protein {ECO:0000269|PubMed:19203586}.
|
| Tissue Specificity |
Widely expressed with lowest expression in liver and spleen. {ECO:0000269|PubMed:10594239}.
|